Title | Bacterial origins of cyclic nucleotide-activated antiviral immune signaling |
Author | |
Corresponding Author | Dinshaw J.,Patel |
Publication Years | 2022-12
|
DOI | |
Source Title | |
ISSN | 1097-2765
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EISSN | 1097-4164
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Volume | 82Issue:24 |
Abstract | Second-messenger-mediated signaling by cyclic oligonucleotides (cOs) composed of distinct base, ring size, and 3′-5′/2′-5′ linkage combinations constitutes the initial trigger resulting in activation of signaling pathways that have an impact on immune-mediated antiviral defense against invading viruses and phages. Bacteria and archaea have evolved CRISPR, CBASS, Pycsar, and Thoeris surveillance complexes that involve cO-mediated activation of effectors resulting in antiviral defense through either targeted nuclease activity, effector oligomerization-mediated depletion of essential cellular metabolites or disruption of host cell membrane functions. Notably, antiviral defense capitalizes on an abortive infection mechanism, whereby infected cells die prior to completion of the phage replication cycle. In turn, phages have evolved small proteins that target and degrade/sequester cOs, thereby suppressing host immunity. This review presents a structure-based mechanistic perspective of recent advances in the field of cO-mediated antiviral defense, in particular highlighting the ancient evolutionary adaptation by metazoans of bacterial cell-autonomous innate immune mechanisms. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
Important Publications | NI Journal Papers
|
SUSTech Authorship | Others
|
Funding Project | NIH[
|
WOS Research Area | Biochemistry & Molecular Biology
; Cell Biology
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WOS Subject | Biochemistry & Molecular Biology
; Cell Biology
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WOS Accession No | WOS:000919688000003
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Publisher | |
ESI Research Field | MOLECULAR BIOLOGY & GENETICS
|
Data Source | 人工提交
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Citation statistics |
Cited Times [WOS]:2
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/416319 |
Department | Department of Biochemistry 南方科技大学医学院 |
Affiliation | 1.Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA 2.Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China |
Recommended Citation GB/T 7714 |
Dinshaw J.,Patel,You,Yu,Ning,Jia. Bacterial origins of cyclic nucleotide-activated antiviral immune signaling[J]. MOLECULAR CELL,2022,82(24).
|
APA |
Dinshaw J.,Patel,You,Yu,&Ning,Jia.(2022).Bacterial origins of cyclic nucleotide-activated antiviral immune signaling.MOLECULAR CELL,82(24).
|
MLA |
Dinshaw J.,Patel,et al."Bacterial origins of cyclic nucleotide-activated antiviral immune signaling".MOLECULAR CELL 82.24(2022).
|
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