中文版 | English
Title

Bacterial origins of cyclic nucleotide-activated antiviral immune signaling

Author
Corresponding AuthorDinshaw J.,Patel
Publication Years
2022-12
DOI
Source Title
ISSN
1097-2765
EISSN
1097-4164
Volume82Issue:24
Abstract

Second-messenger-mediated signaling by cyclic oligonucleotides (cOs) composed of distinct base, ring size, and 3′-5′/2′-5′ linkage combinations constitutes the initial trigger resulting in activation of signaling pathways that have an impact on immune-mediated antiviral defense against invading viruses and phages. Bacteria and archaea have evolved CRISPR, CBASS, Pycsar, and Thoeris surveillance complexes that involve cO-mediated activation of effectors resulting in antiviral defense through either targeted nuclease activity, effector oligomerization-mediated depletion of essential cellular metabolites or disruption of host cell membrane functions. Notably, antiviral defense capitalizes on an abortive infection mechanism, whereby infected cells die prior to completion of the phage replication cycle. In turn, phages have evolved small proteins that target and degrade/sequester cOs, thereby suppressing host immunity. This review presents a structure-based mechanistic perspective of recent advances in the field of cO-mediated antiviral defense, in particular highlighting the ancient evolutionary adaptation by metazoans of bacterial cell-autonomous innate immune mechanisms.

Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
NIH[
WOS Research Area
Biochemistry & Molecular Biology ; Cell Biology
WOS Subject
Biochemistry & Molecular Biology ; Cell Biology
WOS Accession No
WOS:000919688000003
Publisher
ESI Research Field
MOLECULAR BIOLOGY & GENETICS
Data Source
人工提交
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/416319
DepartmentDepartment of Biochemistry
南方科技大学医学院
Affiliation
1.Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
2.Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China
Recommended Citation
GB/T 7714
Dinshaw J.,Patel,You,Yu,Ning,Jia. Bacterial origins of cyclic nucleotide-activated antiviral immune signaling[J]. MOLECULAR CELL,2022,82(24).
APA
Dinshaw J.,Patel,You,Yu,&Ning,Jia.(2022).Bacterial origins of cyclic nucleotide-activated antiviral immune signaling.MOLECULAR CELL,82(24).
MLA
Dinshaw J.,Patel,et al."Bacterial origins of cyclic nucleotide-activated antiviral immune signaling".MOLECULAR CELL 82.24(2022).
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