| Title | Bistable insulin response: The win-win solution for glycemic control |
| Author | |
| Corresponding Author | Ye，Richard; Liu，Guozhen; Chen，Luonan; Wang，Guanyu |
| Publication Years | 2022-12-22
|
| DOI | |
| Source Title | |
| EISSN | 2589-0042
|
| Volume | 25Issue:12 |
| Abstract | To satisfy both the safety and rapidity of glycemic control, muscles’ insulin response must be bistable, as theoretically predicted. Here, we test the bistability hypothesis by combining cellular experiments (to measure the threshold values in vitro) with mathematical modeling (to test the relevance of bistability in vivo). We examine bistability in C2C12 myotubes by both single-cell analysis (Fӧrster resonance energy transfer) and cultured cells analysis (immunoblot). These technologies demonstrate bistable insulin response, with typical switch-on and switch-off thresholds of approximately 300 and 100 pM, respectively. Our mathematical model demonstrates the indispensability of bistability in interpreting experimental data, reveals fine details of plasma glucose-insulin dynamics, and explains unclear phenomena. These results suggest that the body's ability to simultaneously avoid both hypoglycemia and hyperglycemia is mediated by bistability. The switch-on threshold is a promising biomarker for metabolic complications due to its deep quantitative connection with body composition, which is easy to measure. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[12131020]
; National Key Research and Development Program of China[2019YFA0906002]
; National Natural Science Foundation of China[22174121]
; National Natural Science Foundation of China[31930022]
; National Natural Science Foundation of China[32070681]
; National Natural Science Foundation of China[61773196]
; Shenzhen Peacock Plan[KQTD2016053117035204]
|
| Scopus EID | 2-s2.0-85142736595
|
| Data Source | Scopus
|
| Citation statistics |
Cited Times [WOS]:2
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/416462 |
| Department | Department of Biology 生命科学学院 |
| Affiliation | 1.School of Medicine|Life and Health Sciences,The Chinese University of Hong Kong,Shenzhen,518172,China 2.Center for Endocrinology and Metabolic Diseases,Second Affiliated Hospital,The Chinese University of Hong Kong,Shenzhen,518172,China 3.Guangdong Provincial Key Laboratory of Computational Science and Material Design,Shenzhen,518055,China 4.Department of Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 5.Department of Biological Sciences,National University of Singapore,Singapore,117558,Singapore 6.Shenzhen Key Laboratory of Gene Regulation and Systems Biology,School of Life Sciences,Southern University of Science and Technology,Shenzhen,518055,China 7.Bio-Sens Tech Pty Ltd,Sydney,2052,Australia 8.Key Laboratory of Systems Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,Shanghai,200031,China 9.Key Laboratory of Systems Health Science of Zhejiang,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou,310024,China 10.West China Biomedical Big Data Center,Med-X Center for Informatics,West China Hospital,Sichuan University,Chengdu,610041,China |
| First Author Affilication | Department of Biology; School of Life Sciences |
| Corresponding Author Affilication | Department of Biology; School of Life Sciences |
| Recommended Citation GB/T 7714 |
Akhtar，Javed,Han，Yukun,Han，Shangchen,et al. Bistable insulin response: The win-win solution for glycemic control[J]. iScience,2022,25(12).
|
| APA |
Akhtar，Javed.,Han，Yukun.,Han，Shangchen.,Lin，Weiping.,Cao，Chenyu.,...&Wang，Guanyu.(2022).Bistable insulin response: The win-win solution for glycemic control.iScience,25(12).
|
| MLA |
Akhtar，Javed,et al."Bistable insulin response: The win-win solution for glycemic control".iScience 25.12(2022).
|
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