Title | Simultaneous Access to Two Enantio-enriched Alcohols by a Single Ru-Catalyst: Asymmetric Hydrogen Transfer from Racemic Alcohols to Matching Ketones |
Author | |
Corresponding Author | Xu,Chen; Wang,Jianchun; Xing,Xiangyou |
Publication Years | 2022-11-18
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DOI | |
Source Title | |
EISSN | 2155-5435
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Volume | 12Issue:22Pages:14429-14435 |
Abstract | Oxidative kinetic resolution and asymmetric transfer hydrogenation are two classical methods to access chiral secondary alcohols. Described here is an example of cross asymmetric hydrogen transfer between H-donor racemic alcohols and H-acceptor prochiral ketones, which merge these two approaches in one catalytic cycle that could afford two chiral alcohols simultaneously. To create a large equilibrium constant for driving the reversible processes into completion, H-donor alcohols and H-acceptor ketones should have substituents with significantly different properties in sterics or electronics, yet this would cause a substantial challenge for a single catalyst to induce high ee's for both alcohols. Moreover, either enantiomer of a racemic alcohol could be obtained via sequential transfer hydrogenations with a single Ru-catalyst. These results collectively provide efficient access to two distinct enantio-enriched alcohols as well as both enantiomers of single alcohols. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Corresponding
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Funding Project | National Natural Science Foundation of China[K21211026];
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WOS Accession No | WOS:000884840600001
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Scopus EID | 2-s2.0-85141982014
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:2
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/416491 |
Department | Department of Chemistry 深圳格拉布斯研究院 |
Affiliation | 1.School of Chemistry and Chemical Engineering,Harbin Institute of Technology,Harbin,150001,China 2.Shenzhen Grubbs Institute and Department of Chemistry,Guangdong Provincial Key Laboratory of Catalysis,Southern University of Science and Technology,Shenzhen,518055,China 3.Shenzhen Youwei Tech Group,Shenzhen,518057,China |
First Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
Recommended Citation GB/T 7714 |
Chen,Fumin,Jin,Ming Yu,Wang,David Zhigang,et al. Simultaneous Access to Two Enantio-enriched Alcohols by a Single Ru-Catalyst: Asymmetric Hydrogen Transfer from Racemic Alcohols to Matching Ketones[J]. ACS Catalysis,2022,12(22):14429-14435.
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APA |
Chen,Fumin,Jin,Ming Yu,Wang,David Zhigang,Xu,Chen,Wang,Jianchun,&Xing,Xiangyou.(2022).Simultaneous Access to Two Enantio-enriched Alcohols by a Single Ru-Catalyst: Asymmetric Hydrogen Transfer from Racemic Alcohols to Matching Ketones.ACS Catalysis,12(22),14429-14435.
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MLA |
Chen,Fumin,et al."Simultaneous Access to Two Enantio-enriched Alcohols by a Single Ru-Catalyst: Asymmetric Hydrogen Transfer from Racemic Alcohols to Matching Ketones".ACS Catalysis 12.22(2022):14429-14435.
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