Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors
Systemic cancer therapy is always accompanied with toxicity to normal tissue, which has prompted concerted efforts to develop precise treatment strategies. Herein, we firstly develop an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for precise mechanotherapy of tumor. The nanochain comprised nanocomposites of pheophorbide-A (PP) modified iron oxide nanoparticle (IONP) and lanthanide-doped down-conversion NP (DCNP). In a permanent magnetic field, the nanocomposites would be aligned to form nanochain. Next, MnO NPs were subsequently administered to accumulate in tumor as suppliers of Mn, which coordinates with PP to immobilize the nanochain. In a rotating magnetic field, the nanochain would rapidly rotate, leading to apoptosis/necrosis of tumor cell. The nanochain showed high T-MR and NIR-II fluorescence imaging signals, which facilitated guided therapy. The strategy has great potential in practical applications.
NI Journal Papers
National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China["22027805","U21A20377","21874024"] ; Major Project of Science and Technology of Fujian Province[2020HZ06006] ; joint research projects of Health and Education Commission of Fujian Province[2019-WJ-20] ; Natural Science Foundation of Fujian Province[2020J02012]
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Cited Times [WOS]:2
|Document Type||Journal Article|
|Department||Department of Mechanical and Energy Engineering|
1.Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,MOE key laboratory for analytical science of food safety and biology,College of Chemistry,Fuzhou University,Fuzhou,350108,China
2.College of Chemistry,Beijing University of Chemical Technology,Beijing,10010,China
3.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen,Fujian,361005,China
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
Fu，Qinrui,Feng，Hongjuan,Liu，Luntao,et al. Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
Fu，Qinrui.,Feng，Hongjuan.,Liu，Luntao.,Li，Ziqiao.,Li，Jianjie.,...&Song，Jibin.(2022).Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
Fu，Qinrui,et al."Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).
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