中文版 | English
Title

Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors

Author
Corresponding AuthorSong,Jibin
Publication Years
2022
DOI
Source Title
ISSN
1433-7851
EISSN
1521-3773
Abstract
Systemic cancer therapy is always accompanied with toxicity to normal tissue, which has prompted concerted efforts to develop precise treatment strategies. Herein, we firstly develop an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for precise mechanotherapy of tumor. The nanochain comprised nanocomposites of pheophorbide-A (PP) modified iron oxide nanoparticle (IONP) and lanthanide-doped down-conversion NP (DCNP). In a permanent magnetic field, the nanocomposites would be aligned to form nanochain. Next, MnO NPs were subsequently administered to accumulate in tumor as suppliers of Mn, which coordinates with PP to immobilize the nanochain. In a rotating magnetic field, the nanochain would rapidly rotate, leading to apoptosis/necrosis of tumor cell. The nanochain showed high T-MR and NIR-II fluorescence imaging signals, which facilitated guided therapy. The strategy has great potential in practical applications.
Keywords
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Others
Funding Project
National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China["22027805","U21A20377","21874024"] ; Major Project of Science and Technology of Fujian Province[2020HZ06006] ; joint research projects of Health and Education Commission of Fujian Province[2019-WJ-20] ; Natural Science Foundation of Fujian Province[2020J02012]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000888094400001
Publisher
ESI Research Field
CHEMISTRY
Scopus EID
2-s2.0-85143204675
Data Source
Scopus
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/416556
DepartmentDepartment of Mechanical and Energy Engineering
Affiliation
1.Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,MOE key laboratory for analytical science of food safety and biology,College of Chemistry,Fuzhou University,Fuzhou,350108,China
2.College of Chemistry,Beijing University of Chemical Technology,Beijing,10010,China
3.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen,Fujian,361005,China
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China
Recommended Citation
GB/T 7714
Fu,Qinrui,Feng,Hongjuan,Liu,Luntao,et al. Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.
APA
Fu,Qinrui.,Feng,Hongjuan.,Liu,Luntao.,Li,Ziqiao.,Li,Jianjie.,...&Song,Jibin.(2022).Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.
MLA
Fu,Qinrui,et al."Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).
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