Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors

Fu，Qinrui1; Feng，Hongjuan1; Liu，Luntao1; Li，Ziqiao3; Li，Jianjie4; Hu，Jing3; Hu，Chengzhi4; Yan，Xiaohui3; Yang，Huanghao1; Song，Jibin1,2

2022

10.1002/anie.202213319

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   Impact Factor & Quartile

1433-7851

1521-3773

Systemic cancer therapy is always accompanied with toxicity to normal tissue, which has prompted concerted efforts to develop precise treatment strategies. Herein, we firstly develop an approach that enables spatiotemporally controlled formation and rotation of magnetic nanochains in vivo, allowing for precise mechanotherapy of tumor. The nanochain comprised nanocomposites of pheophorbide-A (PP) modified iron oxide nanoparticle (IONP) and lanthanide-doped down-conversion NP (DCNP). In a permanent magnetic field, the nanocomposites would be aligned to form nanochain. Next, MnO NPs were subsequently administered to accumulate in tumor as suppliers of Mn, which coordinates with PP to immobilize the nanochain. In a rotating magnetic field, the nanochain would rapidly rotate, leading to apoptosis/necrosis of tumor cell. The nanochain showed high T-MR and NIR-II fluorescence imaging signals, which facilitated guided therapy. The strategy has great potential in practical applications.

Activatable Probes Fluorescence Probes In Vivo Bioimaging Material Science Self-Assembly

SCI

English

NI Journal Papers

Others

National Key Research and Development Program of China[2020YFA0210800] ; National Natural Science Foundation of China["22027805","U21A20377","21874024"] ; Major Project of Science and Technology of Fujian Province[2020HZ06006] ; joint research projects of Health and Education Commission of Fujian Province[2019-WJ-20] ; Natural Science Foundation of Fujian Province[2020J02012]

Chemistry

Chemistry, Multidisciplinary

WOS:000888094400001

WILEY-V C H VERLAG GMBH

CHEMISTRY

2-s2.0-85143204675

Scopus

1.Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China,MOE key laboratory for analytical science of food safety and biology,College of Chemistry,Fuzhou University,Fuzhou,350108,China
2.College of Chemistry,Beijing University of Chemical Technology,Beijing,10010,China
3.State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen,Fujian,361005,China
4.Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems,Department of Mechanical and Energy Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Fu，Qinrui,Feng，Hongjuan,Liu，Luntao,et al. Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022.

Fu，Qinrui.,Feng，Hongjuan.,Liu，Luntao.,Li，Ziqiao.,Li，Jianjie.,...&Song，Jibin.(2022).Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION.

Fu，Qinrui,et al."Spatiotemporally Controlled Formation and Rotation of Magnetic Nanochains In Vivo for Precise Mechanotherapy of Tumors".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022).