中文版 | English
Title

Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis

Author
Corresponding AuthorWang, Shou-Guo
Publication Years
2022-11-01
DOI
Source Title
ISSN
2041-6520
EISSN
2041-6539
Abstract
A highly efficient enantioselective direct C-H functionalization of beta-carbolines via a Minisci-type radical process under a photo-redox and chiral phosphoric acid cooperative catalytic system has been disclosed. Through this protocol, a wide range of C1 aminoalkylated beta-carbolines were constructed directly with high levels of enantioselectivities from readily available beta-carbolines and alanine-derived redox-active esters. This transformation allows straightforward access to highly valuable enantioenriched beta-carbolines, which are an intriguing structural motif in valuable natural products and synthetic bio-active compounds. This protocol has been utilized as a highly efficient synthetic strategy for the concise asymmetric total synthesis of marine alkaloids eudistomin X, (+)-eudistomidin B and (+)-eudistomidin I.
URL[Source Record]
Indexed By
Language
English
Important Publications
NI Journal Papers
SUSTech Authorship
Corresponding
Funding Project
[22001260] ; [JCYJ20210324101810028] ; [2021A1515010016] ; [ZDSYS20201230165400001] ; [2019M663172] ; [2020B121201002]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000892310700001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:4
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/417051
DepartmentDepartment of Chemistry
Affiliation
1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
Corresponding Author AffilicationDepartment of Chemistry
Recommended Citation
GB/T 7714
Luo, Mu-Peng,Gu, Yi-Jie,Wang, Shou-Guo. Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis[J]. Chemical Science,2022.
APA
Luo, Mu-Peng,Gu, Yi-Jie,&Wang, Shou-Guo.(2022).Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis.Chemical Science.
MLA
Luo, Mu-Peng,et al."Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis".Chemical Science (2022).
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