| Title | Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis |
| Author | |
| Corresponding Author | Wang, Shou-Guo |
| Publication Years | 2022-11-01
|
| DOI | |
| Source Title | |
| ISSN | 2041-6520
|
| EISSN | 2041-6539
|
| Abstract | A highly efficient enantioselective direct C-H functionalization of beta-carbolines via a Minisci-type radical process under a photo-redox and chiral phosphoric acid cooperative catalytic system has been disclosed. Through this protocol, a wide range of C1 aminoalkylated beta-carbolines were constructed directly with high levels of enantioselectivities from readily available beta-carbolines and alanine-derived redox-active esters. This transformation allows straightforward access to highly valuable enantioenriched beta-carbolines, which are an intriguing structural motif in valuable natural products and synthetic bio-active compounds. This protocol has been utilized as a highly efficient synthetic strategy for the concise asymmetric total synthesis of marine alkaloids eudistomin X, (+)-eudistomidin B and (+)-eudistomidin I. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Corresponding
|
| Funding Project | [22001260]
; [JCYJ20210324101810028]
; [2021A1515010016]
; [ZDSYS20201230165400001]
; [2019M663172]
; [2020B121201002]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:000892310700001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:4
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/417051 |
| Department | Department of Chemistry |
| Affiliation | 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen 518055, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China |
| Corresponding Author Affilication | Department of Chemistry |
| Recommended Citation GB/T 7714 |
Luo, Mu-Peng,Gu, Yi-Jie,Wang, Shou-Guo. Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis[J]. Chemical Science,2022.
|
| APA |
Luo, Mu-Peng,Gu, Yi-Jie,&Wang, Shou-Guo.(2022).Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis.Chemical Science.
|
| MLA |
Luo, Mu-Peng,et al."Photocatalytic enantioselective Minisci reaction of beta-carbolines and application to natural product synthesis".Chemical Science (2022).
|
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