Bifunctional tetrazole-carboxylate ligand based Zn(II) complexes: synthesis and their excellent potential anticancer properties

Tan, Li-Tao1; Shen, Ting-Xiao1; Jiang, Jing-Yi2; Zhong, Yu-Jie1; Lin, Fang-Qi2; Xue, Hong2; Yao, Yu-Xin1; Jiang, Xin3; Shen, Lei1; He, Xin4,5

2022-11-22

10.1039/d2ra04768c

RSC ADVANCES   Impact Factor & Quartile

2046-2069

Transition metal coordination complexes have provided cancer treatment with new insights to overcome the limitations of current chemotherapeutic agents. Utilization of bifunctional tetrazole-carboxylate ligands with Zn(ii) obtained two self-assembled complexes [Zn(HL1 (bipy)(3/2)(H2O)]center dot CH3OH center dot 4(H2O) (1) (H3L1 = 1,3,5-tri(2-carboxymethyltetrazol-5-yl) benzene) and [Zn(L-2)(2)(H2O)(2)](2)center dot 2H(2)O (2) (HL2 = (5-pyridin-3-yl-tetrazol-2-yl)-acetic acid). The X-ray diffraction results showed that the two complexes displayed a two-dimensional (2D) layer structure and a one-dimensional (1D) layer structure. Nanocoprecipitation with DSPE-PEG-2000 resulted in the formation of complex nanoparticles (NPS) with excellent water dispersion. In vitro CCK-8 assay indicated the two NPs exert high cytotoxicity and sensitivity and a low half-maximum inhibitory concentration (IC50) towards HeLa than HepG2 cells. In addition, the cytotoxicity was also confirmed by live/dead co-stained experiments. The presented experimental results showed the 1 and 2 NPs were capable of inhibiting cell proliferation in vitro and may help design coordination complex-based anticancer candidates for cancer cells.

SCI

English

Corresponding

Chemistry

Chemistry, Multidisciplinary

WOS:000890888000001

ROYAL SOC CHEMISTRY

Web of Science

1.Changshu Inst Technol, Coll Mat Engn, Jiangsu Lab Adv Funct Mat, Changshu 215500, Peoples R China
2.Guilin Med Univ, Sch Pharm, Guilin 541004, Guangxi, Peoples R China
3.Guilin Med Univ, Affiliated Hosp, Guilin 541000, Guangxi, Peoples R China
4.Southern Univ Sci & Technol SUSTech, Dept Chem, Shenzhen 518055, Peoples R China
5.Southern Univ Sci & Technol SUSTech, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

Tan, Li-Tao,Shen, Ting-Xiao,Jiang, Jing-Yi,et al. Bifunctional tetrazole-carboxylate ligand based Zn(II) complexes: synthesis and their excellent potential anticancer properties[J]. RSC ADVANCES,2022,12(52).

Tan, Li-Tao.,Shen, Ting-Xiao.,Jiang, Jing-Yi.,Zhong, Yu-Jie.,Lin, Fang-Qi.,...&He, Xin.(2022).Bifunctional tetrazole-carboxylate ligand based Zn(II) complexes: synthesis and their excellent potential anticancer properties.RSC ADVANCES,12(52).

Tan, Li-Tao,et al."Bifunctional tetrazole-carboxylate ligand based Zn(II) complexes: synthesis and their excellent potential anticancer properties".RSC ADVANCES 12.52(2022).