中文版 | English
Title

Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones

Author
Corresponding AuthorLiu, Yancheng; Liang, Hong
Publication Years
2022-12-01
DOI
Source Title
EISSN
1420-3049
Volume27Issue:23
Abstract
Due to the abundant and promising biological activities of aromatic hydrazones, it is of great significance to study the biological activities of their metal complexes for the research and development of metal-based drugs. In this review, we focus on the metal complexes of polycyclic aromatic hydrazones, which still do not receive much attention, and summarize the studies related to their biological activities. Although the large number of metal complexes in phenylhydrazone prevent them all from being summarized, the significant value of polycyclic aromatic hydrocarbons themselves (such as naphthalene and anthracene) as pharmacophores are also considered. Therefore, the bioactivities of the metal complexes of naphthylhydrazone and anthrahydrazone are focused on, and the recent research progress on the metal complexes of anthrahydrazone by the authors is also included. In terms of biological activities, these complexes mainly show antibacterial and anticancer activities, along with less bioactivities. The present review demonstrates that the structural design and bioactivities of these complexes are fundamental, which also indicates a certain structure-activity relationship (SAR) in some substructural areas. However, a systematic and comprehensive conclusion of the SAR is still not available, which suggests that more attention should be paid to the bioactivities of the metal complexes of polycyclic aromatic hydrazones since their potential in structural design and biological activity remains to be explored. We hope that this review will attract more researchers to devote their interest and energy into this promising area.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
[21561005] ; [22167005] ; [2020AB26003]
WOS Research Area
Biochemistry & Molecular Biology ; Chemistry
WOS Subject
Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS Accession No
WOS:000896161400001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/417092
DepartmentDepartment of Chemistry
Affiliation
1.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China
First Author AffilicationDepartment of Chemistry
Recommended Citation
GB/T 7714
Liu, Ruixue,Cui, Jingbo,Ding, Tongyan,et al. Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones[J]. MOLECULES,2022,27(23).
APA
Liu, Ruixue,Cui, Jingbo,Ding, Tongyan,Liu, Yancheng,&Liang, Hong.(2022).Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones.MOLECULES,27(23).
MLA
Liu, Ruixue,et al."Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones".MOLECULES 27.23(2022).
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