Title | Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones |
Author | |
Corresponding Author | Liu, Yancheng; Liang, Hong |
Publication Years | 2022-12-01
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DOI | |
Source Title | |
EISSN | 1420-3049
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Volume | 27Issue:23 |
Abstract | Due to the abundant and promising biological activities of aromatic hydrazones, it is of great significance to study the biological activities of their metal complexes for the research and development of metal-based drugs. In this review, we focus on the metal complexes of polycyclic aromatic hydrazones, which still do not receive much attention, and summarize the studies related to their biological activities. Although the large number of metal complexes in phenylhydrazone prevent them all from being summarized, the significant value of polycyclic aromatic hydrocarbons themselves (such as naphthalene and anthracene) as pharmacophores are also considered. Therefore, the bioactivities of the metal complexes of naphthylhydrazone and anthrahydrazone are focused on, and the recent research progress on the metal complexes of anthrahydrazone by the authors is also included. In terms of biological activities, these complexes mainly show antibacterial and anticancer activities, along with less bioactivities. The present review demonstrates that the structural design and bioactivities of these complexes are fundamental, which also indicates a certain structure-activity relationship (SAR) in some substructural areas. However, a systematic and comprehensive conclusion of the SAR is still not available, which suggests that more attention should be paid to the bioactivities of the metal complexes of polycyclic aromatic hydrazones since their potential in structural design and biological activity remains to be explored. We hope that this review will attract more researchers to devote their interest and energy into this promising area. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | Others
|
Funding Project | [21561005]
; [22167005]
; [2020AB26003]
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WOS Research Area | Biochemistry & Molecular Biology
; Chemistry
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WOS Subject | Biochemistry & Molecular Biology
; Chemistry, Multidisciplinary
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WOS Accession No | WOS:000896161400001
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Publisher | |
ESI Research Field | CHEMISTRY
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:1
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/417092 |
Department | Department of Chemistry |
Affiliation | 1.Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China |
First Author Affilication | Department of Chemistry |
Recommended Citation GB/T 7714 |
Liu, Ruixue,Cui, Jingbo,Ding, Tongyan,et al. Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones[J]. MOLECULES,2022,27(23).
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APA |
Liu, Ruixue,Cui, Jingbo,Ding, Tongyan,Liu, Yancheng,&Liang, Hong.(2022).Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones.MOLECULES,27(23).
|
MLA |
Liu, Ruixue,et al."Research Progress on the Biological Activities of Metal Complexes Bearing Polycyclic Aromatic Hydrazones".MOLECULES 27.23(2022).
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