Title | MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer |
Author | |
Corresponding Author | Chen, Yan; Jiang, Yuyang |
Publication Years | 2022-12-01
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DOI | |
Source Title | |
ISSN | 1538-4101
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EISSN | 1551-4005
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Abstract | Colorectal cancer (CRC) becomes the second leading cause of cancer-related deaths in 2020. Emerging studies have indicated that microRNAs (miRNAs) play a key role in tumorigenesis and progression. The dysfunctions of miR-455-3p are observed in many cancers. However, its biological function in CRC remains to be confirmed. By sequencing serum sample, miR-455-3p was found to be up-regulated in CRC patients. RT-qPCR demonstrated that the miR-455-3p expression was both higher in the serum and tumor tissues of CRC patients. Furthermore, it indicated that miR-455-3p had the ability in promoting cell proliferation, suppressing cell apoptosis, and stimulating cell migration. In vivo experiments also showed that miR-455-3p promoted tumor growth. Additionally, H2AFZ was proved as the direct gene target of miR-455-3p by dual-luciferase assay. Taken together, miR-455-3p functioned as a tumor promoter in CRC development by regulating H2AFZ directly. Thus, it has enormous potential as a biomarker in the diagnosis of CRC. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Corresponding
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Funding Project | ~Department of Science and Technology of Guangdong Province[2017B030314083]
; Shenzhen Progression and Reform Committee[2019156]
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WOS Research Area | Cell Biology
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WOS Subject | Cell Biology
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WOS Accession No | WOS:000895841700001
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Publisher | |
ESI Research Field | MOLECULAR BIOLOGY & GENETICS
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/417101 |
Department | Department of Chemistry |
Affiliation | 1.Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Key Lab Chem Biol, Shenzhen, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China 3.Shenzhen Second Peoples Hosp, Dept Gastrointestinal Surg, Shenzhen, Guangdong, Peoples R China 4.Shenzhen Kivita Innovat Drug Discovery Inst, Tsinghua Shenzhen Int Grad Sch, Natl & Local United Engn Lab Personalized Antitumo, Shenzhen, Guangdong, Peoples R China 5.Tsinghua Univ, Sch Pharmaceut Sci, Beijing, Peoples R China 6.Tsinghua Shenzhen Int Grad Sch, State Key Lab Chem Oncogen, Shenzhen 518055, Guangdong, Peoples R China |
Corresponding Author Affilication | Department of Chemistry |
Recommended Citation GB/T 7714 |
Ye, Lizhen,Fan, Tingting,Qin, Ying,et al. MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer[J]. CELL CYCLE,2022.
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APA |
Ye, Lizhen.,Fan, Tingting.,Qin, Ying.,Qiu, Cheng.,Li, Lulu.,...&Jiang, Yuyang.(2022).MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer.CELL CYCLE.
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MLA |
Ye, Lizhen,et al."MicroRNA-455-3p accelerate malignant progression of tumor by targeting H2AFZ in colorectal cancer".CELL CYCLE (2022).
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