Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation

Wang, Guimei1; Wang, Xiaolin2; Zheng, Xiaoyue1; Sun, Shuqin1; Zhao, Jing1; Long, Ying3; Mao, Yongjun1

2022-12-01

10.1016/j.neures.2022.08.005

NEUROSCIENCE RESEARCH   Impact Factor & Quartile

0168-0102

1872-8111

Aging is fundamental to neurodegeneration and dementia. Preventing oxidative stress and neuroinflammation are potential methods of delaying the onset of aging-associated neurodegenerative diseases. The acidic oligosaccharide sugar chain (AOSC) and hyperbaric oxygen (HBO) can increase the expression of antioxidants and have a neuroprotective function. In this study, we investigate the ability of AOSC, HBO, and AOSC + HBO to prevent D-gal-induced brain senescence. The Morris water maze and Y-maze test results showed that all three therapies significantly attenuated D-gal-induced memory disorders. A potential mechanism of this action was decreasing elevated levels of oxidative stress and neuroinflammation. The western blot and morphological results showed that all three therapies decreased D-gal-induced neuroinflammation and downregulated inflammatory mediators including the nuclear factor kappa-light-chain-enhancer of activated B cells, cyclooxygenase-2, interleukin1 beta, and tumor necrosis factor alpha. Taken together, our results indicated that AOSC, HBO, and AOSC + HBO therapies attenuated D-gal-induced brain aging in mice by repressing RAGE/NF-KB-induced inflammation, the activation of astrocytes and microglia, and a decrease in neuronal degeneration. These could be useful therapies for treating age-related neurodegenerative diseases such as Alzheimer's disease. Furthermore, HBO combined with AOSC had a better effect than HBO or AOSC alone.

D-galactose Acidic oligosaccharide sugar chain Hyperbaric oxygen Oxidative stress Neurodegeneration Neuroinflammation

SCI

English

Corresponding

National Natural Science Foundation of China[31571829]

Neurosciences & Neurology

Neurosciences

WOS:000893251000005

ELSEVIER IRELAND LTD

NEUROSCIENCE & BEHAVIOR

Web of Science

1.Qingdao Univ, Affiliated Hosp, Dept Geriatr Med, Qingdao 266000, Shandong, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Hyperbar Ox, Shenzhen 518020, Guangdong, Peoples R China

Wang, Guimei,Wang, Xiaolin,Zheng, Xiaoyue,et al. Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation[J]. NEUROSCIENCE RESEARCH,2022,185.

Wang, Guimei.,Wang, Xiaolin.,Zheng, Xiaoyue.,Sun, Shuqin.,Zhao, Jing.,...&Mao, Yongjun.(2022).Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation.NEUROSCIENCE RESEARCH,185.

Wang, Guimei,et al."Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation".NEUROSCIENCE RESEARCH 185(2022).