Title | Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation |
Author | |
Corresponding Author | Long, Ying; Mao, Yongjun |
Publication Years | 2022-12-01
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DOI | |
Source Title | |
ISSN | 0168-0102
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EISSN | 1872-8111
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Volume | 185 |
Abstract | Aging is fundamental to neurodegeneration and dementia. Preventing oxidative stress and neuroinflammation are potential methods of delaying the onset of aging-associated neurodegenerative diseases. The acidic oligosaccharide sugar chain (AOSC) and hyperbaric oxygen (HBO) can increase the expression of antioxidants and have a neuroprotective function. In this study, we investigate the ability of AOSC, HBO, and AOSC + HBO to prevent D-gal-induced brain senescence. The Morris water maze and Y-maze test results showed that all three therapies significantly attenuated D-gal-induced memory disorders. A potential mechanism of this action was decreasing elevated levels of oxidative stress and neuroinflammation. The western blot and morphological results showed that all three therapies decreased D-gal-induced neuroinflammation and downregulated inflammatory mediators including the nuclear factor kappa-light-chain-enhancer of activated B cells, cyclooxygenase-2, interleukin1 beta, and tumor necrosis factor alpha. Taken together, our results indicated that AOSC, HBO, and AOSC + HBO therapies attenuated D-gal-induced brain aging in mice by repressing RAGE/NF-KB-induced inflammation, the activation of astrocytes and microglia, and a decrease in neuronal degeneration. These could be useful therapies for treating age-related neurodegenerative diseases such as Alzheimer's disease. Furthermore, HBO combined with AOSC had a better effect than HBO or AOSC alone. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Corresponding
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Funding Project | National Natural Science Foundation of China[31571829]
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WOS Research Area | Neurosciences & Neurology
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WOS Subject | Neurosciences
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WOS Accession No | WOS:000893251000005
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Publisher | |
ESI Research Field | NEUROSCIENCE & BEHAVIOR
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/417103 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Qingdao Univ, Affiliated Hosp, Dept Geriatr Med, Qingdao 266000, Shandong, Peoples R China 2.Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China 3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Hyperbar Ox, Shenzhen 518020, Guangdong, Peoples R China |
Corresponding Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Wang, Guimei,Wang, Xiaolin,Zheng, Xiaoyue,et al. Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation[J]. NEUROSCIENCE RESEARCH,2022,185.
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APA |
Wang, Guimei.,Wang, Xiaolin.,Zheng, Xiaoyue.,Sun, Shuqin.,Zhao, Jing.,...&Mao, Yongjun.(2022).Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation.NEUROSCIENCE RESEARCH,185.
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MLA |
Wang, Guimei,et al."Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation".NEUROSCIENCE RESEARCH 185(2022).
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