中文版 | English
Title

Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation

Author
Corresponding AuthorLong, Ying; Mao, Yongjun
Publication Years
2022-12-01
DOI
Source Title
ISSN
0168-0102
EISSN
1872-8111
Volume185
Abstract
Aging is fundamental to neurodegeneration and dementia. Preventing oxidative stress and neuroinflammation are potential methods of delaying the onset of aging-associated neurodegenerative diseases. The acidic oligosaccharide sugar chain (AOSC) and hyperbaric oxygen (HBO) can increase the expression of antioxidants and have a neuroprotective function. In this study, we investigate the ability of AOSC, HBO, and AOSC + HBO to prevent D-gal-induced brain senescence. The Morris water maze and Y-maze test results showed that all three therapies significantly attenuated D-gal-induced memory disorders. A potential mechanism of this action was decreasing elevated levels of oxidative stress and neuroinflammation. The western blot and morphological results showed that all three therapies decreased D-gal-induced neuroinflammation and downregulated inflammatory mediators including the nuclear factor kappa-light-chain-enhancer of activated B cells, cyclooxygenase-2, interleukin1 beta, and tumor necrosis factor alpha. Taken together, our results indicated that AOSC, HBO, and AOSC + HBO therapies attenuated D-gal-induced brain aging in mice by repressing RAGE/NF-KB-induced inflammation, the activation of astrocytes and microglia, and a decrease in neuronal degeneration. These could be useful therapies for treating age-related neurodegenerative diseases such as Alzheimer's disease. Furthermore, HBO combined with AOSC had a better effect than HBO or AOSC alone.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China[31571829]
WOS Research Area
Neurosciences & Neurology
WOS Subject
Neurosciences
WOS Accession No
WOS:000893251000005
Publisher
ESI Research Field
NEUROSCIENCE & BEHAVIOR
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/417103
DepartmentShenzhen People's Hospital
Affiliation
1.Qingdao Univ, Affiliated Hosp, Dept Geriatr Med, Qingdao 266000, Shandong, Peoples R China
2.Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Hyperbar Ox, Shenzhen 518020, Guangdong, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Wang, Guimei,Wang, Xiaolin,Zheng, Xiaoyue,et al. Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation[J]. NEUROSCIENCE RESEARCH,2022,185.
APA
Wang, Guimei.,Wang, Xiaolin.,Zheng, Xiaoyue.,Sun, Shuqin.,Zhao, Jing.,...&Mao, Yongjun.(2022).Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation.NEUROSCIENCE RESEARCH,185.
MLA
Wang, Guimei,et al."Acidic oligosaccharide sugar chain combined with hyperbaric oxygen delays D-galactose-induced brain senescence in mice via attenuating oxidative stress and neuroinflammation".NEUROSCIENCE RESEARCH 185(2022).
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