| Title | Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety |
| Author | |
| Corresponding Author | Liu, Ying-Guo; Chen, Xingkuan; Liu, Hongmei |
| Publication Years | 2022-12-01
|
| DOI | |
| Source Title | |
| ISSN | 1612-1872
|
| EISSN | 1612-1880
|
| Abstract | Phthalidyl promoiety has been used in several drugs, but they were all marketed in racemic form. The pharmaceutical effects of each enantiomer have not been clearly demonstrated. In this project, an anticancer chemotherapy drug, chlorambucil, was modified as enantiopure phthalidyl prodrugs. The enantiomers, together with phthalidyl unit and their racemic mixture, were then subject to the in vivo bioactivity tests against B16F10 melanoma cells. It was found that proper chirality within the promoiety had noticeably better in vivo pharmacological effects than the parent drug, the enantiomer and racemic mixture. This merit perhaps could be extended from the phthalidyl prodrugs to other chirality containing prodrugs. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Natural Science Foundation of China[22101266]
; International Postdoctoral Exchange Fellowship Program[YJ20210304]
; China Postdoctoral Science Foundation[2022M722865]
; Jiangsu Department of Science and Technology[BE2020647]
; Social Development Project of Xuzhou Department of Science and Technology[KC20079]
; Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications[2020B08]
; Fundamental Research Funds["11620416","202201020559"]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Chemistry
|
| WOS Subject | Biochemistry & Molecular Biology
; Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:000894621900001
|
| Publisher | |
| ESI Research Field | ENVIRONMENT/ECOLOGY
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/417106 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450001, Peoples R China 2.Zhengzhou Univ, Henan Inst Adv Technol, Zhengzhou 450001, Peoples R China 3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China 4.Jinan Univ, Dept Chem, Guangdong Prov Key Lab Funct Supramol Coordinat Ma, Guangzhou 510632, Guangdong, Peoples R China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Zhang, Long,Cheng, Yisa,Liu, Ying-Guo,et al. Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety[J]. CHEMISTRY & BIODIVERSITY,2022.
|
| APA |
Zhang, Long,Cheng, Yisa,Liu, Ying-Guo,Chen, Xingkuan,&Liu, Hongmei.(2022).Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety.CHEMISTRY & BIODIVERSITY.
|
| MLA |
Zhang, Long,et al."Anticancer Effect of Chlorambucil Enhanced by Chiral Phthalidyl Promoiety".CHEMISTRY & BIODIVERSITY (2022).
|
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