Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases

Zhang, Xiaoyan1; Lee, Weithye2; Bian, Jin-Song1

2022-12-01

10.3390/cells11244075

CELLS   Impact Factor & Quartile

2073-4409

Na+/K+-ATPase (NKA), a large transmembrane protein, is expressed in the plasma membrane of most eukaryotic cells. It maintains resting membrane potential, cell volume and secondary transcellular transport of other ions and neurotransmitters. NKA consumes about half of the ATP molecules in the brain, which makes NKA highly sensitive to energy deficiency. Neurodegenerative diseases (NDDs) are a group of diseases characterized by chronic, progressive and irreversible neuronal loss in specific brain areas. The pathogenesis of NDDs is sophisticated, involving protein misfolding and aggregation, mitochondrial dysfunction and oxidative stress. The protective effect of NKA against NDDs has been emerging gradually in the past few decades. Hence, understanding the role of NKA in NDDs is critical for elucidating the underlying pathophysiology of NDDs and identifying new therapeutic targets. The present review focuses on the recent progress involving different aspects of NKA in cellular homeostasis to present in-depth understanding of this unique protein. Moreover, the essential roles of NKA in NDDs are discussed to provide a platform and bright future for the improvement of clinical research in NDDs.

Na+ K+-ATPase neurodegenerative diseases protein-protein interaction mitochondrial dysfunction oxidative stress

SCI

English

First ; Corresponding

[82173800] ; [81872865] ; [KQTD20200820113040070]

Cell Biology

Cell Biology

WOS:000900513800001

MDPI

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Dept Pharmacol, Shenzhen 518055, Peoples R China
2.Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore

Zhang, Xiaoyan,Lee, Weithye,Bian, Jin-Song. Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases[J]. CELLS,2022,11(24).

Zhang, Xiaoyan,Lee, Weithye,&Bian, Jin-Song.(2022).Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases.CELLS,11(24).

Zhang, Xiaoyan,et al."Recent Advances in the Study of Na+/K+-ATPase in Neurodegenerative Diseases".CELLS 11.24(2022).