Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols

Li, Xiang1,2,3; Yang, Xintuo1,2; Chen, Pinhong1,2; Liu, Guosheng1,2,3

2022-12-01

10.1021/jacs.2c11428

Journal of the American Chemical Society   Impact Factor & Quartile

0002-7863

1520-5126

As a general method for the synthesis of alcohols, the direct oxygenation of alkenes is difficult to afford linear alcohols. Herein, we communicate the remote hydro-oxygenation of alkenes under palladium catalysis, in which both terminal and internal alkenes are suitable to yield the corresponding linear alcohols efficiently. A compatible SelectFluor/silane redox system plays an essential role for the excellent chemo-and regioselectivities. The reaction features a broad substrate scope and excellent functional group compatibility.

SCI

English

NI Journal Papers ; NI论文

Corresponding

National Key R&D Program of China[2021YFA1500100] ; National Nature Science Foundation of China["91956202","22171279","21790330","21821002"] ; Science and Technology Commission of Shanghai Municipality["20JC1417000","21520780100","19590750400"] ; Key Research Program of Frontier Science[QYZDJSSW-SLH055] ; International Partnershi p Program of the Chinese Academy of Sciences[121731KYSB20190016]

Chemistry

Chemistry, Multidisciplinary

WOS:000896951100001

AMER CHEMICAL SOC

Web of Science

1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hongkong Joint Lab Chem Synth, Shanghai 200032, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China

Li, Xiang,Yang, Xintuo,Chen, Pinhong,et al. Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols[J]. Journal of the American Chemical Society,2022.

Li, Xiang,Yang, Xintuo,Chen, Pinhong,&Liu, Guosheng.(2022).Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols.Journal of the American Chemical Society.

Li, Xiang,et al."Palladium-Catalyzed Remote Hydro-Oxygenation of Internal Alkenes: An Efficient Access to Primary Alcohols".Journal of the American Chemical Society (2022).