Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis

Guo, Hanhan1; Huang, Jianghong2,3; Liang, Yujie4; Wang, Daping1,5; Zhang, Huawei1,6

2022-12-12

10.1186/s40001-022-00926-2

EUROPEAN JOURNAL OF MEDICAL RESEARCH   Impact Factor & Quartile

0949-2321

2047-783X

Osteoarthritis (OA) is a common chronic disabling disease that affects hundreds of millions of people around the world. The most important pathological feature is the rupture and loss of articular cartilage, and the characteristics of avascular joint tissues lead to limited repair ability. Currently, there is no effective treatment to prevent cartilage degeneration. Studies on the mechanism of cartilage metabolism revealed that hypoxia-inducible factors (HIFs) are key regulatory genes that maintain the balance of cartilage catabolism-matrix anabolism and are considered to be the major OA regulator and promising OA treatment target. Although the exact mechanism of HIFs in OA needs to be further clarified, many drugs that directly or indirectly act on HIF signaling pathways have been confirmed by animal experiments and regarded as promising treatments for OA. Targeting HIFs will provide a promising strategy for the development of new OA drugs. This article reviews the regulation of HIFs on intra-articular cartilage homeostasis and its influence on the progression of osteoarthritis and summarizes the recent advances in OA therapies targeting the HIF system.

SCI

English

First ; Corresponding

Guangdong Basic and Applied Basic Research Foundation[GJHZ20190820115203714] ; National Natural Science Foundation of China[2021A1515220134] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials["31900046","81972085","82172465"] ; [2022B1212010003]

Research & Experimental Medicine

Medicine, Research & Experimental

WOS:000897916500001

BMC

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China
2.Shenzhen Univ, Shenzhen Peoples Hosp 2, Hlth Sci Ctr, Dept Spine Surg & Orthoped,Affiliated Hosp 1, Shenzhen 518035, Peoples R China
3.Tsinghua Univ, Shenzhen Int Grad Sch, Class 9 2020, Shenzhen 518055, Peoples R China
4.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen 518020, Peoples R China
5.Shenzhen Univ, Shenzhen Peoples Hosp 2, Guangdong Prov Res Ctr Artificial Intelligence & D, Dept Orthoped,Affiliated Hosp 1,Shenzhen Intellige, Shenzhen 518000, Peoples R China
6.Southern Univ Sci & Technol, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China

Guo, Hanhan,Huang, Jianghong,Liang, Yujie,et al. Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis[J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH,2022,27(1).

Guo, Hanhan,Huang, Jianghong,Liang, Yujie,Wang, Daping,&Zhang, Huawei.(2022).Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis.EUROPEAN JOURNAL OF MEDICAL RESEARCH,27(1).

Guo, Hanhan,et al."Focusing on the hypoxia-inducible factor pathway: role, regulation, and therapy for osteoarthritis".EUROPEAN JOURNAL OF MEDICAL RESEARCH 27.1(2022).