中文版 | English
Title

Myeloid-derived suppressor cell: A crucial player in autoimmune diseases

Author
Corresponding AuthorCui, Dawei; Xie, Jue
Publication Years
2022-12-09
DOI
Source Title
ISSN
1664-3224
Volume13
Abstract
Myeloid-derived suppressor cells (MDSCs) are identified as a highly heterogeneous group of immature cells derived from bone marrow and play critical immunosuppressive functions in autoimmune diseases. Accumulating evidence indicates that the pathophysiology of autoimmune diseases was closely related to genetic mutations and epigenetic modifications, with the latter more common. Epigenetic modifications, which involve DNA methylation, covalent histone modification, and non-coding RNA-mediated regulation, refer to inheritable and potentially reversible changes in DNA and chromatin that regulate gene expression without altering the DNA sequence. Recently, numerous reports have shown that epigenetic modifications in MDSCs play important roles in the differentiation and development of MDSCs and their suppressive functions. The molecular mechanisms of differentiation and development of MDSCs and their regulatory roles in the initiation and progression of autoimmune diseases have been extensively studied, but the exact function of MDSCs remains controversial. Therefore, the biological and epigenetic regulation of MDSCs in autoimmune diseases still needs to be further characterized. This review provides a detailed summary of the current research on the regulatory roles of DNA methylation, histone modifications, and non-coding RNAs in the development and immunosuppressive activity of MDSCs, and further summarizes the distinct role of MDSCs in the pathogenesis of autoimmune diseases, in order to provide help for the diagnosis and treatment of diseases from the perspective of epigenetic regulation of MDSCs.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000901383300001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/417348
DepartmentSchool of Medicine
Affiliation
1.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Blood Transfus, Hangzhou, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
Recommended Citation
GB/T 7714
Xu, Dandan,Li, Cheng,Xu, Yushan,et al. Myeloid-derived suppressor cell: A crucial player in autoimmune diseases[J]. Frontiers in Immunology,2022,13.
APA
Xu, Dandan,Li, Cheng,Xu, Yushan,Huang, Mingyue,Cui, Dawei,&Xie, Jue.(2022).Myeloid-derived suppressor cell: A crucial player in autoimmune diseases.Frontiers in Immunology,13.
MLA
Xu, Dandan,et al."Myeloid-derived suppressor cell: A crucial player in autoimmune diseases".Frontiers in Immunology 13(2022).
Files in This Item:
There are no files associated with this item.
Related Services
Fulltext link
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Xu, Dandan]'s Articles
[Li, Cheng]'s Articles
[Xu, Yushan]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Xu, Dandan]'s Articles
[Li, Cheng]'s Articles
[Xu, Yushan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, Dandan]'s Articles
[Li, Cheng]'s Articles
[Xu, Yushan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.