Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights
An excessive neutrophil count is recognized as a valuable predictor of inflammation and is associated with a higher risk of adverse cardiac events in patients with heart failure. Our understanding of the effectors used by neutrophils to inflict proinflammatory actions needs to be advanced. Recently, emerging evidence has demonstrated a causative role of neutrophil-derived alarmins (i.e. S100A8/A9) in aggravating cardiac injuries by induction of inflammation. In parallel with the neutrophil count, high circulating levels of S100A8/A9 proteins powerfully predict mortality in patients with heart failure. As such, a deeper understanding of the biological functions of neutrophil-derived S100A8/A9 proteins would offer novel therapeutic insights. Here, the basic biology of S100A8/A9 proteins and their pleiotropic roles in cardiovascular diseases are discussed, focusing on heart failure. We also consider the evidence that therapeutic targeting of S100A8/A9 proteins by the humanized vaccine, antibodies or inhibitors is able to town down inflammatory injuries.
|ESI Research Field|
PHARMACOLOGY & TOXICOLOGY
Cited Times [WOS]:0
|Document Type||Journal Article|
|Department||School of Public Health and Emergency Management|
1.Shenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, 518055, China.
2.Department of Cardiology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
|First Author Affilication||Southern University of Science and Technology|
|First Author's First Affilication||Southern University of Science and Technology|
Bo,Bai,Yun,Xu,Haibo,Chen. Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights[J]. BRITISH JOURNAL OF PHARMACOLOGY,2023,180(5):573-588.
Bo,Bai,Yun,Xu,&Haibo,Chen.(2023).Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights.BRITISH JOURNAL OF PHARMACOLOGY,180(5),573-588.
Bo,Bai,et al."Pathogenic roles of neutrophil-derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights".BRITISH JOURNAL OF PHARMACOLOGY 180.5(2023):573-588.
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