| Title | The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing |
| Author | |
| Corresponding Author | Yongmei,Ge; Lijun,Lin; Bin,Tang |
| Joint first author | Qili,Sun; Zhanpeng,Liu; Chao,Xie |
| Publication Years | 2022-12
|
| DOI | |
| Source Title | |
| ISSN | 0927-7765
|
| EISSN | 1873-4367
|
| Volume | 222 |
| Abstract | Physical exercise has long been considered an essential regulator of bone formation. Recent studies have shown that brain-derived neurotrophic factor (BDNF) is an important cytokine released during physical exercise to promote osteogenic differentiation and facilitate the bone defect healing process. In this study, we developed a multifunctional system 7,8-DHF@ZIF-8, which combines the superior osteogenesis and angiogenesis properties of ZIF-8 and the unique capability of 7,8-DHF to mimic the function of BDNF to compensate for the routine physical exercise missed during the bone defect period. Various material characterizations were performed to confirm the successful synthesis of 7,8-DHF@ZIF-8. Drug release experiments suggested that 7,8-DHF@ZIF-8 could achieve slow diffusive release under physiological conditions within seven days. In vitro cell experiments indicated that low concentrations of ZIF-8 and 7,8-DHF@ZIF-8 could significantly promote the proliferation of MC3T3-E1 cells. Moreover, as proved by RT-QPCR analysis, incorporating 7,8-DHF into ZIF-8 could further enhance osteogenesis and angiogenesis-related gene expression. Therefore, we believe that the multifunctional drug system 7,8-DHF@ZIF-8 should have promising applications to facilitate bone defect healing. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; 共同第一
; Corresponding
|
| Publisher | |
| ESI Research Field | BIOLOGY & BIOCHEMISTRY
|
| Data Source | 人工提交
|
| Publication Status | 在线出版
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/420654 |
| Department | Department of Biomedical Engineering 工学院_材料科学与工程系 |
| Affiliation | 1.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China 2.Department of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, PR China 3.Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, PR China 4.Guangdong Provincial Key Laboratory of Advanced Biomaterials, PR China |
| First Author Affilication | Department of Biomedical Engineering |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| First Author's First Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Qili,Sun,Zhanpeng,Liu,Chao,Xie,et al. The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,222.
|
| APA |
Qili,Sun.,Zhanpeng,Liu.,Chao,Xie.,Liqiu,Hu.,Huili,Li.,...&Bin,Tang.(2022).The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing.COLLOIDS AND SURFACES B-BIOINTERFACES,222.
|
| MLA |
Qili,Sun,et al."The development of novel multifunctional drug system 7,8-DHF@ZIF-8 and its potential application in bone defect healing".COLLOIDS AND SURFACES B-BIOINTERFACES 222(2022).
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| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 1-s2.0-S092777652200（3705KB） | Restricted Access | -- | ||||
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