中文版 | English
Title

Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study

Author
Corresponding AuthorLu, Xiangfeng
Publication Years
2022-12-01
DOI
Source Title
EISSN
2072-6643
Volume14Issue:23
Abstract

The aim of this study was to evaluate the association between fruit intake and stroke risk considering the genetic predisposition. We used data from 34,871 participants from the project of Prediction for Atherosclerotic Cardiovascular Disease Risk in China (China-PAR project) from 2007 to 2020. A polygenic risk score comprising 534 genetic variants associated with stroke and its related factors was constructed to categorize individuals into low, intermediate, and high genetic risk groups. The associations of genetic and fruit intake with incident stroke were assessed by the Cox proportional hazard regression. We documented 2586 incident strokes during a median follow-up of 11.2 years. Compared with fruit intake < 200 g/week, similar relative risk reductions in stroke with adherence to fruit intake > 100 g/day across the genetic risk categories were observed (28-32%), but the absolute risk reductions were relatively larger in the highest genetic risk group (p for trend = 0.03). In comparison to those with a fruit intake < 200 g/week, those with a fruit intake >100 g/day in the low, intermediate, and high genetic risk groups had an average of 1.45 (95% CI, 0.61-2.31), 2.12 (1.63-2.59), and 2.19 (1.13-3.22) additional stroke-free years at aged 35, respectively. Our findings suggest that individuals with a high genetic risk could gain more absolute risk reductions and stroke-free years than those with a low genetic risk from increasing fruit intake for the stroke primary prevention.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
WOS Research Area
Nutrition & Dietetics
WOS Subject
Nutrition & Dietetics
WOS Accession No
WOS:000896523500001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:2
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/420661
DepartmentSchool of Medicine
Affiliation
1.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Dept Epidemiol, Natl Ctr Cardiovasc Dis, Beijing 100037, Peoples R China
2.Chinese Acad Med Sci, Key Lab Cardiovasc Epidemiol, Beijing 100037, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Natl Inst Environm Hlth, Beijing 100021, Peoples R China
4.Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin 300070, Peoples R China
5.Guangdong Prov Peoples Hosp, Div Epidemiol, Guangzhou 510080, Peoples R China
6.Cardiovasc Inst, Guangzhou 510080, Peoples R China
7.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing 211166, Peoples R China
8.Fujian Prov Hosp, Dept Cardiol, Fuzhou 350014, Peoples R China
9.Shandong Acad Med Sci, Inst Basic Med, Cardiocerebrovasc Control & Res Ctr, Jinan 250062, Peoples R China
10.Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou 450001, Peoples R China
11.Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Hlth Sci Ctr, Shenzhen 518071, Peoples R China
12.School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China
Recommended Citation
GB/T 7714
Wang, Jun,Li, Jianxin,Liu, Fangchao,et al. Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study[J]. NUTRIENTS,2022,14(23).
APA
Wang, Jun.,Li, Jianxin.,Liu, Fangchao.,Huang, Keyong.,Yang, Xueli.,...&Lu, Xiangfeng.(2022).Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study.NUTRIENTS,14(23).
MLA
Wang, Jun,et al."Genetic Predisposition, Fruit Intake and Incident Stroke: A Prospective Chinese Cohort Study".NUTRIENTS 14.23(2022).
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