| Title | Cell-Derived Vesicles for mRNA Delivery |
| Author | |
| Corresponding Author | Li, Bin |
| Publication Years | 2022-12-01
|
| DOI | |
| Source Title | |
| EISSN | 1999-4923
|
| Volume | 14Issue:12 |
| Abstract | The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made on the development of mRNA delivery systems, many challenges, such as the dose-limiting toxicity and specific delivery to extrahepatic tissues, still remain. Cell-derived vesicles, a type of endogenous membranous particle secreted from living cells, can be leveraged to load mRNA during or after their biogenesis. Currently, they have received increasing interest for mRNA delivery due to their natural origin, good biocompatibility, cell-specific tropism, and unique ability to cross physiological barriers. In this review, we provide an overview of recent advances in the naturally occurring mRNA delivery platforms and their biomedical applications. Furthermore, the future perspectives on clinical translation of cell-derived vesicles have been discussed. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | [82072053]
; [RCYX20200714114539061]
; [JCYJ20190806150018265]
|
| WOS Research Area | Pharmacology & Pharmacy
|
| WOS Subject | Pharmacology & Pharmacy
|
| WOS Accession No | WOS:000903221700001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/420779 |
| Department | Shenzhen People's Hospital 南方科技大学医学院 |
| Affiliation | 1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Infect Dis, Shenzhen 518020, Peoples R China 2.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China 3.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China |
| First Author Affilication | Shenzhen People's Hospital |
| Corresponding Author Affilication | Shenzhen People's Hospital; School of Medicine |
| First Author's First Affilication | Shenzhen People's Hospital |
| Recommended Citation GB/T 7714 |
Li, Zhenghua,Liu, Zhen,Wu, Jiacai,et al. Cell-Derived Vesicles for mRNA Delivery[J]. PHARMACEUTICS,2022,14(12).
|
| APA |
Li, Zhenghua,Liu, Zhen,Wu, Jiacai,&Li, Bin.(2022).Cell-Derived Vesicles for mRNA Delivery.PHARMACEUTICS,14(12).
|
| MLA |
Li, Zhenghua,et al."Cell-Derived Vesicles for mRNA Delivery".PHARMACEUTICS 14.12(2022).
|
| Files in This Item: | There are no files associated with this item. | |||||
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