中文版 | English
Title

Cell-Derived Vesicles for mRNA Delivery

Author
Corresponding AuthorLi, Bin
Publication Years
2022-12-01
DOI
Source Title
EISSN
1999-4923
Volume14Issue:12
Abstract
The clinical translation of messenger mRNA (mRNA)-based therapeutics requires safe and effective delivery systems. Although considerable progress has been made on the development of mRNA delivery systems, many challenges, such as the dose-limiting toxicity and specific delivery to extrahepatic tissues, still remain. Cell-derived vesicles, a type of endogenous membranous particle secreted from living cells, can be leveraged to load mRNA during or after their biogenesis. Currently, they have received increasing interest for mRNA delivery due to their natural origin, good biocompatibility, cell-specific tropism, and unique ability to cross physiological barriers. In this review, we provide an overview of recent advances in the naturally occurring mRNA delivery platforms and their biomedical applications. Furthermore, the future perspectives on clinical translation of cell-derived vesicles have been discussed.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First ; Corresponding
Funding Project
[82072053] ; [RCYX20200714114539061] ; [JCYJ20190806150018265]
WOS Research Area
Pharmacology & Pharmacy
WOS Subject
Pharmacology & Pharmacy
WOS Accession No
WOS:000903221700001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/420779
DepartmentShenzhen People's Hospital
南方科技大学医学院
Affiliation
1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Infect Dis, Shenzhen 518020, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital;  School of Medicine
First Author's First AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Li, Zhenghua,Liu, Zhen,Wu, Jiacai,et al. Cell-Derived Vesicles for mRNA Delivery[J]. PHARMACEUTICS,2022,14(12).
APA
Li, Zhenghua,Liu, Zhen,Wu, Jiacai,&Li, Bin.(2022).Cell-Derived Vesicles for mRNA Delivery.PHARMACEUTICS,14(12).
MLA
Li, Zhenghua,et al."Cell-Derived Vesicles for mRNA Delivery".PHARMACEUTICS 14.12(2022).
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