First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor

Chou, Tiansheng1,2; Huang, Xiaosheng3; Liu, Jiawei2; Liu, Xinhua3; Zeng, Kun3; Yan, Zonghui3; Mei, Shaoyi3; Sun, Liangnan3; Xi, Wenqun3; Ni, Jinglan4; Zi, Jin2; Zhao, Jun4; Liu, Siqi1,2

2022-12-01

10.3390/metabo12121220

METABOLITES   Impact Factor & Quartile

2218-1989

The quantitative level of steroid hormones (SHs) in some body fluids have been accepted for clinical diagnosis, whereas their distribution in aqueous humor (AH) is unknown yet. Herein, a profiling study was conducted with a total of 171 AH and 107 plasma samples using liquid chromatography coupled with tandem mass spectrometry (LC MS/MS). For the first time, six kinds of SHs in AH were quantitatively estimated, and their abundances were ranked at cortisol (F), corticosterone (COR), androstenedione (A2), and 11-deoxycortisol (11DOC). The corresponding abundance of all SHs in AH was significantly lower than those in plasma, while there was a lack of a proportional relationship with the abundance of plasma SHs. Dehydroepiandrosterone sulfate, the most abundant plasma SH, was undetectable in AH, implying that the blood-aqueous barrier might specifically block its transferral. Axial myopia generally results from many factors throughout the entire eye from tissues and molecules; furthermore, the correlation of AH SHs and axial myopia was assessed to look for their indication in such myopia. The panel with five kinds of AH SHs (F, COR, CORT, ALD and A2) was functional as a discriminator for axial myopia and control. The abundance of SHs, therefore, has a specific distribution in AH and can potentially contribute to axial myopia.

steroid hormone aqueous humor blood-aqueous barrier (BAB) axial length (AL)

SCI

English

Corresponding

Biochemistry & Molecular Biology

Biochemistry & Molecular Biology

WOS:000902730300001

MDPI

Web of Science

1.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China
2.Beijing Genom Inst BGI, Dept Prote, Shenzhen 518000, Peoples R China
3.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen 518040, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Peoples R China

Chou, Tiansheng,Huang, Xiaosheng,Liu, Jiawei,et al. First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor[J]. METABOLITES,2022,12(12).

Chou, Tiansheng.,Huang, Xiaosheng.,Liu, Jiawei.,Liu, Xinhua.,Zeng, Kun.,...&Liu, Siqi.(2022).First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor.METABOLITES,12(12).

Chou, Tiansheng,et al."First Evidence Indicates the Physiology- and Axial-Myopia-Dependent Profiles of Steroid Hormones in Aqueous Humor".METABOLITES 12.12(2022).