Title | Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees |
Author | |
Corresponding Author | Guo, X. Edward |
Publication Years | 2023-02-01
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DOI | |
Source Title | |
ISSN | 8756-3282
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EISSN | 1873-2763
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Volume | 167 |
Abstract | Anterior cruciate ligament (ACL) tear leads to post-traumatic osteoarthritis (PTOA), a significant clinical burden worldwide that currently has no cure. Recent studies suggest a role of subchondral bone adaptations in the development of PTOA. Particularly, microstructural changes in the rod-and-plate microstructure of subchondral bone may precede and contribute to OA progression. In this study, we quantified microstructural changes in subchondral trabecular rods and plates after ACL-transection for the first time in the well-established preclinical canine model of PTOA and investigated the therapeutic potentials of a bisphosphonate (zoledronate) and NSAID treatment (meloxicam). Unilateral hindlimb ACL transection was performed on skeletally-mature (2-year-old, N = 20) and juvenile (10-month-old, N = 20) male beagles. Animals were assigned to 4 groups (N = 5): ACLT, un-operated control, ACLT with zoledronate, and ACLT with meloxicam treatment. Subchondral bone microstruc-ture was evaluated by micro-computed tomography and cartilage integrity was evaluated histologically. We found that ACL-induced subchondral bone changes depended on skeletal maturity of animals. In mature animals, significant loss of trabecular plates that resulted in reduced PR ratio occurred at Month 1 and persisted until Month 8. Zoledronate treatment prevented trabecular plate loss while meloxicam treatment did not. Whether cartilage degeneration is also attenuated warrants further investigation. In juvenile animals that have not reached skeletal maturity, transient changes in trabecular plate and rod microstructure occurred at Month 3 but not Month 9. Neither zoledronate nor meloxicam treatment attenuated bone microstructural changes or cartilage damages. Findings from this study suggest that early inhibition of bone resorption by bisphosphonate after injury may be a promising therapeutic approach to prevent alterations in subchondral bone microstructure associated with PTOA. Our results further demonstrate that pathogenesis of PTOA may differ between adolescent and adult patients and therefore require distinct management strategies. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | First
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Funding Project | [202201020476]
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WOS Research Area | Endocrinology & Metabolism
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WOS Subject | Endocrinology & Metabolism
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WOS Accession No | WOS:000899593700009
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Publisher | |
ESI Research Field | CLINICAL MEDICINE
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Data Source | Web of Science
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/420812 |
Department | Department of Biomedical Engineering |
Affiliation | 1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China 2.Columbia Univ, Dept Biomed Engn, Bone Bioengn Lab, New York, NY USA 3.Univ Hong Kong, LKS Fac Med, Dept Orthopead & Traumatol, Hong Kong, Peoples R China 4.Guangdong Second Prov Gen Hosp, Dept Orthopead & Traumatol, Guangzhou, Guangdong, Peoples R China 5.Columbia Univ, Dept Biomed Engn, 351 Engn Terrace,Mail Code 8904,1210 Amsterdam Ave, New York, NY 10027 USA |
First Author Affilication | Department of Biomedical Engineering |
First Author's First Affilication | Department of Biomedical Engineering |
Recommended Citation GB/T 7714 |
Xu, Lei,Hu, Yizhong Jenny,Peng, Ying,et al. Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees[J]. BONE,2023,167.
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APA |
Xu, Lei.,Hu, Yizhong Jenny.,Peng, Ying.,Wang, Zexi.,Wang, Jingyi.,...&Guo, X. Edward.(2023).Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees.BONE,167.
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MLA |
Xu, Lei,et al."Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees".BONE 167(2023).
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