中文版 | English
Title

Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees

Author
Corresponding AuthorGuo, X. Edward
Publication Years
2023-02-01
DOI
Source Title
ISSN
8756-3282
EISSN
1873-2763
Volume167
Abstract
Anterior cruciate ligament (ACL) tear leads to post-traumatic osteoarthritis (PTOA), a significant clinical burden worldwide that currently has no cure. Recent studies suggest a role of subchondral bone adaptations in the development of PTOA. Particularly, microstructural changes in the rod-and-plate microstructure of subchondral bone may precede and contribute to OA progression. In this study, we quantified microstructural changes in subchondral trabecular rods and plates after ACL-transection for the first time in the well-established preclinical canine model of PTOA and investigated the therapeutic potentials of a bisphosphonate (zoledronate) and NSAID treatment (meloxicam). Unilateral hindlimb ACL transection was performed on skeletally-mature (2-year-old, N = 20) and juvenile (10-month-old, N = 20) male beagles. Animals were assigned to 4 groups (N = 5): ACLT, un-operated control, ACLT with zoledronate, and ACLT with meloxicam treatment. Subchondral bone microstruc-ture was evaluated by micro-computed tomography and cartilage integrity was evaluated histologically. We found that ACL-induced subchondral bone changes depended on skeletal maturity of animals. In mature animals, significant loss of trabecular plates that resulted in reduced PR ratio occurred at Month 1 and persisted until Month 8. Zoledronate treatment prevented trabecular plate loss while meloxicam treatment did not. Whether cartilage degeneration is also attenuated warrants further investigation. In juvenile animals that have not reached skeletal maturity, transient changes in trabecular plate and rod microstructure occurred at Month 3 but not Month 9. Neither zoledronate nor meloxicam treatment attenuated bone microstructural changes or cartilage damages. Findings from this study suggest that early inhibition of bone resorption by bisphosphonate after injury may be a promising therapeutic approach to prevent alterations in subchondral bone microstructure associated with PTOA. Our results further demonstrate that pathogenesis of PTOA may differ between adolescent and adult patients and therefore require distinct management strategies.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
First
Funding Project
[202201020476]
WOS Research Area
Endocrinology & Metabolism
WOS Subject
Endocrinology & Metabolism
WOS Accession No
WOS:000899593700009
Publisher
ESI Research Field
CLINICAL MEDICINE
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/420812
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China
2.Columbia Univ, Dept Biomed Engn, Bone Bioengn Lab, New York, NY USA
3.Univ Hong Kong, LKS Fac Med, Dept Orthopead & Traumatol, Hong Kong, Peoples R China
4.Guangdong Second Prov Gen Hosp, Dept Orthopead & Traumatol, Guangzhou, Guangdong, Peoples R China
5.Columbia Univ, Dept Biomed Engn, 351 Engn Terrace,Mail Code 8904,1210 Amsterdam Ave, New York, NY 10027 USA
First Author AffilicationDepartment of Biomedical Engineering
First Author's First AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Xu, Lei,Hu, Yizhong Jenny,Peng, Ying,et al. Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees[J]. BONE,2023,167.
APA
Xu, Lei.,Hu, Yizhong Jenny.,Peng, Ying.,Wang, Zexi.,Wang, Jingyi.,...&Guo, X. Edward.(2023).Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees.BONE,167.
MLA
Xu, Lei,et al."Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees".BONE 167(2023).
Files in This Item:
There are no files associated with this item.
Related Services
Fulltext link
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Xu, Lei]'s Articles
[Hu, Yizhong Jenny]'s Articles
[Peng, Ying]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Xu, Lei]'s Articles
[Hu, Yizhong Jenny]'s Articles
[Peng, Ying]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xu, Lei]'s Articles
[Hu, Yizhong Jenny]'s Articles
[Peng, Ying]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.