Oxygen Saturation Ranges for Healthy Newborns within 2 h at Altitudes between 847 and 4,360 m: A Prospective Cohort Study

Li, Yangfang1; Ze, Bi2,3; Zhang, Tiesong4; Liu, Xiaomei1; Gao, Jin1; Mao, Hui5; Qin, Mingcai6; Lai, Yinzhen7; Jiu, Suo Nan Ba8; Li, Guoyun9; Du, Kun1; Yu, Zhangbin8,10; Zhou, Wenhao3

2022-12-01

10.1159/000527266

Neonatology   Impact Factor & Quartile

1661-7800

1661-7819

Introduction: The partial oxygen pressure in the air decreases with increasing altitude. This study was designed to compare the pulse oxygen saturation (SpO(2)) among well full-term neonates at different altitudes during their first 2 h after birth and to establish cutoff values of SpO(2) identifying hypoxemia between 30 and 120 min after birth. Methods: A multisite prospective cohort study was conducted at five participating hospitals from the Chinese High Altitude Neonatal Medicine Alliance. Healthy full-term infants were recruited and divided into four groups based on the altitude. Preductal SpO(2) was recorded at 10 min, 10-30 min, and 30-120 min after birth. The 2.5th percentile of the SpO(2) distribution range was considered as the cutoff for identifying hypoxemia at each altitude. Results: A total of 727 infants were eligible for analysis. The SpO(2) of neonates at different altitudes increased with the time after birth. A higher altitude was associated with lower SpO(2), especially Shangri-La (3,509 m) and Yushu (4,360 m). The cutoff SpO(2) for identifying hypoxemia during 30-120 min after birth were 94% in Xishuangbanna (847 m), 92% in Kunming (1,983 m), 89% in Shangri-La (3,509 m), and 83% in Yushu (4,360 m). Conclusion: An increase in altitude, especially Shangri-La (3,509 m) and Yushu (4,360 m), had a significant impact on SpO(2) among healthy full-term neonates during their first 2 h of life. Establishing the cutoff value of SpO(2) for identifying hypoxemia during the early postnatal period serves to optimize the oxygen therapy at different altitudes.

Pulse oxygen saturation Newborn Altitude

SCI

English

Corresponding

[2019IC052]

Pediatrics

Pediatrics

WOS:000893825400001

KARGER

Web of Science

1.Kunming Childrens Hosp, Dept Neonatol, Kunming, Yunnan, Peoples R China
2.Tibet Autonomous Reg Peoples Hosp, Dept Pediat, Lhasa, Peoples R China
3.Fudan Univ, Dept Neonatol, Childrens Hosp, Shanghai, Peoples R China
4.Kunming Childrens Hosp, Dept Pediat, Kunming, Yunnan, Peoples R China
5.Yunnan Univ, Reprod Med Res Ctr, Dept Obstet, Affiliated Hosp, Kunming, Yunnan, Peoples R China
6.Maternal & Child Hlth Hosp Shangri La, Dept Pediat, Diqing, Peoples R China
7.Diqing Tibetan Autonomous Prefecture Peoples Hosp, Dept Pediat, Diqing, Peoples R China
8.Qinghai Univ, Dept Neonatol, Affiliated Hosp, Xining, Peoples R China
9.Xishuangbanna Dai Autonomous Prefecture Peoples H, Dept Pediat, Xishuangbanna, Peoples R China
10.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Dept Neonatol,Shenzhen Peoples Hosp,Clin Med Coll, Shenzhen, Peoples R China

Li, Yangfang,Ze, Bi,Zhang, Tiesong,et al. Oxygen Saturation Ranges for Healthy Newborns within 2 h at Altitudes between 847 and 4,360 m: A Prospective Cohort Study[J]. Neonatology,2022.

Li, Yangfang.,Ze, Bi.,Zhang, Tiesong.,Liu, Xiaomei.,Gao, Jin.,...&Zhou, Wenhao.(2022).Oxygen Saturation Ranges for Healthy Newborns within 2 h at Altitudes between 847 and 4,360 m: A Prospective Cohort Study.Neonatology.

Li, Yangfang,et al."Oxygen Saturation Ranges for Healthy Newborns within 2 h at Altitudes between 847 and 4,360 m: A Prospective Cohort Study".Neonatology (2022).