中文版 | English
Title

The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma

Author
Corresponding AuthorLiu, Hongmei; Yu, Rutong
Publication Years
2023-12-31
DOI
Source Title
ISSN
1071-7544
EISSN
1521-0464
Volume30Issue:1
Abstract
Temozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its drug resistance properties. O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme, which can repair the DNA damage caused by TMZ. A large number of clinical data show that reducing the expression of MGMT can enhance the chemotherapeutic efficacy of TMZ. Therefore, in order to improve the resistance of glioma to TMZ, an angiopep-2 (A2) modified nanoprodrug of polytemozolomide (P(TMZ)n) that combines with MGMT siRNA (siMGMT) targeting MGMT was developed (A2/T/D/siMGMT). It not only increased the amount of TMZ within tumor lesion site, but also reduced MGMT expression in glioma. The in vitro experiments indicated that the A2/T/D/siMGMT effectively enhanced the cellular uptake of TMZ and siMGMT, and resulted in a significant cell apoptosis and cytotoxicity in the glioma cells. The in vivo experiments showed that glioma growth was inhibited and the survival time of animals were prolonged remarkably after A2/T/D/siMGMT was injected via tail vein. The results showed that the therapeutic effect of A2/T/D/siMGMT in the treatment of glioma was significantly improved.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
[82072796] ; [BE2020642] ; [KYCX21_2657] ; [KYCX22_2950] ; [M2020081]
WOS Research Area
Pharmacology & Pharmacy
WOS Subject
Pharmacology & Pharmacy
WOS Accession No
WOS:000904946100001
Publisher
ESI Research Field
PHARMACOLOGY & TOXICOLOGY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/424061
DepartmentDepartment of Biomedical Engineering
Affiliation
1.Xuzhou Med Univ, Inst Nervous Syst Dis, Xuzhou, Peoples R China
2.Xuzhou Med Univ, Dept Neurosurg, Affiliated Hosp, Xuzhou, Peoples R China
3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen, Peoples R China
Corresponding Author AffilicationDepartment of Biomedical Engineering
Recommended Citation
GB/T 7714
Xu, Haoyue,Zhang, Yongkang,Li, Linfeng,et al. The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma[J]. DRUG DELIVERY,2023,30(1).
APA
Xu, Haoyue.,Zhang, Yongkang.,Li, Linfeng.,Ren, Yanhong.,Qian, Feng.,...&Yu, Rutong.(2023).The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma.DRUG DELIVERY,30(1).
MLA
Xu, Haoyue,et al."The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma".DRUG DELIVERY 30.1(2023).
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