| Title | MALDI-TOF-MS for rapid screening analysis of M-protein in serum |
| Author | |
| Corresponding Author | Li, Jie; Liang, Chao; Ji, Ling |
| Publication Years | 2022-12-15
|
| DOI | |
| Source Title | |
| ISSN | 2234-943X
|
| Volume | 12 |
| Abstract | Monoclonal immunoglobin (M-protein) is a serum biomarker for the diagnosis of plasma cell dyscrasias. Despite limitation of analytical sensitivity and resolution, serum protein electrophoresis and immunofixation electrophoresis are still the front-line tests for the detection of M-proteins. Herein, we developed a MALDI-TOF Mass spectrometry-based method for the screening test of M-proteins in human serum. Based on the unique mass signature of different immunoglobin isotypes, M-Proteins could be rapidly identified and typed. The method demonstrated with high analytical performance and throughput, rapid and simple, which could be a new choice for the diagnosis of plasma cell dyscrasias. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China[82104216]
; Guangdong Basic and Applied Basic Research Foundation[2020A1515011450]
; Shenzhen Project of Science and Technology["JCYJ20190809094007719","JCYJ20190809095203586"]
; fund of "Sanming" Project of Medicine in Shenzhen, China[SZSM201812088]
|
| WOS Research Area | Oncology
|
| WOS Subject | Oncology
|
| WOS Accession No | WOS:000905449300001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/424640 |
| Department | Department of Biology 生命科学学院 |
| Affiliation | 1.Peking Univ, Dept Lab Med, Shenzhen Hosp, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen, Peoples R China 3.Hong Kong Baptist Univ, Inst Integrated Bioinfomedicine & Translat Sci IBT, Sch Chinese Med, Hong Kong, Peoples R China 4.Beijing Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing, Peoples R China |
| Corresponding Author Affilication | Department of Biology; School of Life Sciences |
| Recommended Citation GB/T 7714 |
Li, Jie,Xu, Anping,Xie, Weijie,et al. MALDI-TOF-MS for rapid screening analysis of M-protein in serum[J]. Frontiers in Oncology,2022,12.
|
| APA |
Li, Jie.,Xu, Anping.,Xie, Weijie.,Li, Bowen.,Yan, Cunliang.,...&Ji, Ling.(2022).MALDI-TOF-MS for rapid screening analysis of M-protein in serum.Frontiers in Oncology,12.
|
| MLA |
Li, Jie,et al."MALDI-TOF-MS for rapid screening analysis of M-protein in serum".Frontiers in Oncology 12(2022).
|
| Files in This Item: | There are no files associated with this item. | |||||
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