| Title | The fabrication and evaluation of silver nanoparticle-based keratin scaffolds |
| Author | |
| Corresponding Author | Fan, Jie; Chen, Rouxi; Liu, Yong |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 0885-3282
|
| EISSN | 1530-8022
|
| Abstract | The biotoxicity caused by focus releasing of Ag, which associated with the Ag loading mode, is a problematic issue that need to be solved for practical utilization of the keratin based wound dressing. In this study, keratin/AgNPs blend scaffolds (Ker/Ag) and keratin scaffolds with AgNPs attached on the scaffold's wall surface (Ag@Ker) were prepared. Structure and physical properties of the scaffolds were tested and investigated. In comparison to the Ag@Ker scaffolds, the Ker/Ag scaffolds with uniform dispersion of AgNPs have larger tensile strength and slower degradation rate. Both kind of scaffolds present excellent antibacterial property with 10 mu g mL(-1) AgNPs addition, while the Ker/Ag displayed a linear Ag releasing ratio in the first 5-7 days, which is beneficial for obtaining a continuous antibacterial property and avoiding the biotoxicity caused by focus release of Ag. Correspondingly, cytotoxicity assay further reveals that the continuously slow release of Ag of the Ker/Ag scaffolds accelerated the proliferation of cell. Infectious animal models and histological studies showed that the Ker/Ag scaffolds can effectively inhibit the inflammatory response and accelerate epithelialization. Thus, it can be concluded that the Ker/Ag scaffolds with uniform dispersion of AgNPs are more attractive as wound repair materials. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| WOS Research Area | Engineering
; Materials Science
|
| WOS Subject | Engineering, Biomedical
; Materials Science, Biomaterials
|
| WOS Accession No | WOS:000908088600001
|
| Publisher | |
| ESI Research Field | CLINICAL MEDICINE
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/424654 |
| Department | Academy for Advanced Interdisciplinary Studies |
| Affiliation | 1.Tiangong Univ, Sch Text Sci & Engn, Tianjin, Peoples R China 2.North China Univ Sci & Technol, Med Expt Cente, Tangshan, Peoples R China 3.North China Univ Sci & Technol, Lab Anim Ctr, Tangshan, Peoples R China 4.AF Gen Hosp PAL, Dermatol Dept, Beijing, Peoples R China 5.North China Univ Sci & Technol, Med Res Ctr, Tangshan, Peoples R China 6.DongGuan Beyclean Environm Protect Technol Co LTD, Dongguan, Peoples R China 7.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen, Peoples R China 8.Tiangong Univ, Sch Text Sci & Engn, Binshui West Rd 399, Tianjin 300387, Peoples R China 9.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, 1088 Xueyuan Ave, Shenzhen 518055, Peoples R China |
| Corresponding Author Affilication | Academy for Advanced Interdisciplinary Studies |
| Recommended Citation GB/T 7714 |
Lei, Tongda,Fan, Jie,Wang, Yongheng,et al. The fabrication and evaluation of silver nanoparticle-based keratin scaffolds[J]. JOURNAL OF BIOMATERIALS APPLICATIONS,2023.
|
| APA |
Lei, Tongda.,Fan, Jie.,Wang, Yongheng.,Cao, Fuyuan.,Yang, Qingqi.,...&Liu, Yong.(2023).The fabrication and evaluation of silver nanoparticle-based keratin scaffolds.JOURNAL OF BIOMATERIALS APPLICATIONS.
|
| MLA |
Lei, Tongda,et al."The fabrication and evaluation of silver nanoparticle-based keratin scaffolds".JOURNAL OF BIOMATERIALS APPLICATIONS (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
; 
Edit Comment