Title | Omicron variants escape the persistent SARS-CoV-2-specific antibody response in 2-year COVID-19 convalescents regardless of vaccination |
Author | |
Corresponding Author | Ju, Bin; Zhang, Zheng |
Publication Years | 2023-12-31
|
DOI | |
Source Title | |
EISSN | 2222-1751
|
Volume | 12Issue:1 |
Abstract | With the ongoing COVID-19 pandemic and the emergence of various SARS-CoV-2 variants, a comprehensive evaluation of long-term efficacy of antibody response in convalescent individuals is urgently needed. Several longitudinal studies had reported the antibody dynamics after SARS-CoV-2 acute infection, but the follow-up was mostly limited to 1 year or 18 months at the maximum. In this study, we investigated the durability, potency, and susceptibility to immune evasion of SARS-CoV-2-specific antibody in COVID-19 convalescents for 2 years after discharge. These results showed the persistent antibody-dependent immunity could protect against the WT and Delta variant to some extent. However, the Omicron variants (BA.1, BA.2, and BA.4/5) largely escaped this preexisting immunity in recovered individuals. Furthermore, we revealed that inactivated vaccines (BBIBP-CorV, CoronaVac, or KCONVAC) could improve the plasma neutralization and help to maintain the broadly neutralizing antibodies at a certain level. Notably, with the time-dependent decline of antibody, 1-dose or 2-dose vaccination strategy seemed not to be enough to provide immune protection against the emerging variants. Overall, these results facilitated our understanding of SARS-CoV-2-induced antibody memory, contributing to the development of immunization strategy against SARS-CoV-2 variants for such a large number of COVID-19 survivors. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | First
; Corresponding
|
Funding Project | National Natural Science Foundation of China[82025022]
; National Key Plan for Scientific Research and Development of China["92169204","82002140","82171752","82101861"]
; Guangdong Basic and Applied Basic Research Foundation[2021YFC0864500]
; Science and Technology Innovation Committee of Shenzhen Municipality["2021B1515020034","2019A1515011197","2021A1515011009","2020A1515110656"]
; Shenzhen Natural Science Foundation["JSGG20220226085550001","JSGG20200207155251653","JSGG20200807171401008","JSGG20210901145200002","KQTD20200909113758004"]
; [JCYJ20190809115617365]
; [JCYJ20210324115611032]
; [JCYJ20220530163405012]
|
WOS Research Area | Immunology
; Infectious Diseases
; Microbiology
|
WOS Subject | Immunology
; Infectious Diseases
; Microbiology
|
WOS Accession No | WOS:000905262700001
|
Publisher | |
Data Source | Web of Science
|
Citation statistics |
Cited Times [WOS]:6
|
Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/424732 |
Department | School of Medicine 南方科技大学第一附属医院 南方科技大学第二附属医院 |
Affiliation | 1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Inst Hepatol,Sch Med ,Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China 2.Guangdong Key Lab Antiinfect Drug Qual Evaluat, Shenzhen, Peoples R China 3.Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatment, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Affiliated Hosp 2, Inst Hepatol,Sch Med ,Natl Clin Res Ctr Infect Dis, Shenzhen 518112, Guangdong, Peoples R China 5.Guangdong Key Lab Anti Infect Drug Qual Evaluat, Shenzhen 518112, Guangdong, Peoples R China 6.Chinese Acad Med Sci, Shenzhen Res Ctr Communicable Dis Diag & Treatment, Shenzhen 518112, Guangdong, Peoples R China |
First Author Affilication | School of Medicine; The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
Corresponding Author Affilication | School of Medicine; The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
First Author's First Affilication | School of Medicine; The Third People's Hospital of Shenzhen; Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Wang, Miao,Zhou, Bing,Fan, Qing,et al. Omicron variants escape the persistent SARS-CoV-2-specific antibody response in 2-year COVID-19 convalescents regardless of vaccination[J]. EMERGING MICROBES & INFECTIONS,2023,12(1).
|
APA |
Wang, Miao.,Zhou, Bing.,Fan, Qing.,Zhou, Xinrong.,Liao, Xuejiao.,...&Zhang, Zheng.(2023).Omicron variants escape the persistent SARS-CoV-2-specific antibody response in 2-year COVID-19 convalescents regardless of vaccination.EMERGING MICROBES & INFECTIONS,12(1).
|
MLA |
Wang, Miao,et al."Omicron variants escape the persistent SARS-CoV-2-specific antibody response in 2-year COVID-19 convalescents regardless of vaccination".EMERGING MICROBES & INFECTIONS 12.1(2023).
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