Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa

Feng, Qishun1; Zhou, Jianuan2,3; Zhang, Lianhui2,3; Fu, Yang1; Yang, Liang1

2022-12-01

10.1080/1040841X.2022.2154140

CRITICAL REVIEWS IN MICROBIOLOGY   Impact Factor & Quartile

1040-841X

1549-7828

The opportunistic human pathogen Pseudomonas aeruginosa can cause severe infections in immunocompromized people or cystic fibrosis (CF) patients. Because of its remarkable ability to invade the host and withstand the bacteriocidal effect of most conventional antibiotics, the infection caused by P. aeruginosa has become a major concern for human health. The switch from acute to chronic infection is governed by the second messenger bis-(3 '-5 ')-cyclic dimeric guanosine mono-phosphate (c-di-GMP) in P. aeruginosa, and c-di-GMP is now recognized to regulate many important biological processes in pathogenesis. The c-di-GMP signalling mechanisms in P. aeruginosa have been studied extensively in the past decade, revealing complicated c-di-GMP metabolism and signalling network. In this review, the underlying mechanisms of this signalling network will be discussed, mainly focussing on how environmental cues regulate c-di-GMP signalling, protein-protein interaction mediated functional regulation, heterogeneity of c-di-GMP and cross talk between c-di-GMP signalling and other signalling systems. Understanding the molecular mechanism underlying the complex c-di-GMP signalling network would be beneficial for developing therapeutic approaches and antibacterial agents to combat the threat from P. aeruginosa.

Pseudomonas aeruginosa c-di-GMP signalling environmental cues protein-protein interaction heterogeneity

SCI

English

First ; Corresponding

China Postdoctoral Science Foundation[2021M691431] ; Natural Research Foundation of China["31330002","31972230"] ; Guangdong Natural Science Foundation for Distinguished Young Scholar[2020B1515020003] ; Guangdong Natural Science Foundation[2020A1515011534] ; Guangdong Technological Innovation Strategy of Special Funds[2018B020205003] ; Key Projects of Guangzhou Science and Technology Plan[201804020066] ; Guangzhou Municipal Science and Technology Bureau[201607020044] ; Southern University of Science and Technology[Y01416110]

Microbiology

Microbiology

WOS:000900504700001

TAYLOR & FRANCIS LTD

MICROBIOLOGY

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Shenzhen, Guangdong, Peoples R China
2.South China Agr Univ, Integrat Microbiol Res Ctr, Guangdong Prov Key Lab Microbial Signals & Dis Con, Guangzhou, Peoples R China
3.South China Agr Univ, Guangdong Lab Lingnan Modern Agr, Guangzhou, Peoples R China

Feng, Qishun,Zhou, Jianuan,Zhang, Lianhui,et al. Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa[J]. CRITICAL REVIEWS IN MICROBIOLOGY,2022.

Feng, Qishun,Zhou, Jianuan,Zhang, Lianhui,Fu, Yang,&Yang, Liang.(2022).Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa.CRITICAL REVIEWS IN MICROBIOLOGY.

Feng, Qishun,et al."Insights into the molecular basis of c-di-GMP signalling in Pseudomonas aeruginosa".CRITICAL REVIEWS IN MICROBIOLOGY (2022).