中文版 | English
Title

HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population

Author
Corresponding AuthorZhao, Jun
Publication Years
2022-12-09
DOI
Source Title
ISSN
2314-8861
EISSN
2314-7156
Volume2022
Abstract
Previous studies have shown that HLA gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between HLA-III gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of HLA-III genes (including HSP70-1, HSP70-2, HSP70-hom, TNF-alpha, TNF-beta, C2, and CFB) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-beta in the patient group were significantly higher than those in healthy controls (Corrected P P-c=0.040, OR=1.45; P-c=0.033, OR=1.45; P-c=0.045, OR=1.58, respectively). The frequency of T allele at rs12190359 of HSP70-1 was significantly lower in PSS patients than those in healthy controls (P-c=0.018 and OR=0.10). The frequencies of the CCT haplotype of HSP70-1 gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of HSP70 gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls (P-c=0.024, OR=0.10; P-c=0.048, OR=0.10, respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of TNF-beta gene might be risk factors for PSS, while the T allele at rs12190359 of HSP70-1 gene and specific haplotypes of the HSP70-1 and HSP70 genes might be protective factors for PSS.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Science, Technology and Innovation Commission of Shenzhen Municipality["JCYJ20180228164400218","JCYJ20210324113610029"] ; Sanming Project of Medicine in Shenzhen[SZSM201812090] ; Medical Science and Technology Research Fund Project of Guangdong Province[A2022403]
WOS Research Area
Immunology
WOS Subject
Immunology
WOS Accession No
WOS:000900158100001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/424851
DepartmentShenzhen People's Hospital
Affiliation
1.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Peoples R China
2.Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen 518040, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Ophthalmol,Clin Med Coll 2, Shenzhen 518020, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Bai, Wei,Huang, Xiaosheng,Shen, Xiaoli,et al. HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population[J]. Journal of Immunology Research,2022,2022.
APA
Bai, Wei.,Huang, Xiaosheng.,Shen, Xiaoli.,Ye, Ye.,Peng, Shiming.,...&Zhao, Jun.(2022).HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population.Journal of Immunology Research,2022.
MLA
Bai, Wei,et al."HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population".Journal of Immunology Research 2022(2022).
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