中文版 | English
Title

Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma

Author
Corresponding AuthorWang, Xia; Sha, Ou
Publication Years
2023-01-11
DOI
Source Title
EISSN
1422-0067
Volume24Issue:2
Abstract

Trichosanthin (TCS) is a type I ribosome-inactivating protein extracted from the tuberous root of the plant Trichosanthes. TCS shows promising potential in clinical drug abortion, anti-tumor and immunological regulation. However, the molecular mechanisms of its anti-tumor and immune regulation properties are still not well discovered. In the present study, we investigated the anti-tumor activity of TCS in hepatocellular carcinoma (HCC), both in vitro and in vivo. Both HCC cell lines and xenograft tumor tissues showed considerable growth inhibition after they were treated with TCS. TCS provoked caspase-mediated apoptosis in HCC cells and xenograft tumor tissues. The recruitment of CD8(+) T cells to HCC tissues and the expression of chemokines, CCL2 and CCL22, were promoted upon TCS treatment. In addition, TCS induced an upregulation of Granzyme B (GrzB), TNF-alpha and IFN-gamma in HCC tissues, which are the major cytotoxic mediators produced by T cells. Furthermore, TCS also resulted in an increase of mannose-6-phosphate receptor (M6PR), the major receptor of GrzB, in HCC tissues. In summary, these results suggest that TCS perhaps increases T-cell immunity via promoting the secretion of chemokines and accelerating the entry of GrzB to HCC cells, which highlights the potential role of TCS in anti-tumor immunotherapy.

Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China[81773939] ; Technology Foundation of Shenzhen City[JCYJ20210324094005015]
WOS Research Area
Biochemistry & Molecular Biology ; Chemistry
WOS Subject
Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS Accession No
WOS:000914778200001
Publisher
ESI Research Field
CHEMISTRY
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/425004
DepartmentDepartment of Biology
生命科学学院
Affiliation
1.Shenzhen Univ, Sch Dent, Med Sch, Shenzhen 518000, Peoples R China
2.Hong Kong Baptist Univ, Fac Sci, Dept Biol, Hongkong 999077, Peoples R China
3.Shenzhen Univ, Sch Basic Med Sci, Dept Anat & Histol, Med Sch, Shenzhen 518000, Peoples R China
4.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen 518000, Peoples R China
5.Univ Macau, Fac Hlth Sci, Macau, Peoples R China
6.Shantou Univ, Guangdong Prov Key Lab Infect Dis & Mol Immunopath, Med Coll, Shantou, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kaifang,Wang, Xiaona,Zhang, Minghuan,et al. Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(2).
APA
Wang, Kaifang.,Wang, Xiaona.,Zhang, Minghuan.,Ying, Zhenguang.,Zhu, Zeyao.,...&Sha, Ou.(2023).Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(2).
MLA
Wang, Kaifang,et al."Trichosanthin Promotes Anti-Tumor Immunity through Mediating Chemokines and Granzyme B Secretion in Hepatocellular Carcinoma".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.2(2023).
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