中文版 | English
Title

Active DNA demethylation in plants: 20 years of discovery and beyond

Author
Corresponding AuthorZhang, Heng; Gong, Zhizhong; Zhu, Jian-Kang
Publication Years
2022-12-01
DOI
Source Title
ISSN
1672-9072
EISSN
1744-7909
Volume64Issue:12
Abstract
Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA. However, removing the methyl group from a modified cytosine is chemically difficult and therefore, the underlying mechanism of demethylation had remained unclear for many years. The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation. In the 20 years since ROS1 was discovered, our understanding of this active DNA demethylation pathway, as well as its regulation and biological functions in plants, has greatly expanded. These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation, with potential applications in epigenome editing to facilitate crop breeding and gene therapy.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
[31922008] ; [XDB27040108] ; [X20200101] ; [2021YFA1300401]
WOS Research Area
Biochemistry & Molecular Biology ; Plant Sciences
WOS Subject
Biochemistry & Molecular Biology ; Plant Sciences
WOS Accession No
WOS:000905780800002
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/425166
DepartmentInstitute of Advanced Biotechnology
生命科学学院
Affiliation
1.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Ctr Excellence Mol Plant Sci, State Key Lab Mol Plant Genet, Shanghai 200032, Peoples R China
2.China Agr Univ, Coll Biol Sci, State Key Lab Plant Physiol & Biochem, Beijing 100193, Peoples R China
3.Hebei Univ, Inst Life Sci & Green Dev, Sch Life Sci, Baoding 071002, Peoples R China
4.Southern Univ Sci & Technol, Inst Adv Biotechnol, Sch Life Sci, Shenzhen 518055, Peoples R China
Corresponding Author AffilicationInstitute of Advanced Biotechnology;  School of Life Sciences
Recommended Citation
GB/T 7714
Zhang, Heng,Gong, Zhizhong,Zhu, Jian-Kang. Active DNA demethylation in plants: 20 years of discovery and beyond[J]. Journal of Integrative Plant Biology,2022,64(12).
APA
Zhang, Heng,Gong, Zhizhong,&Zhu, Jian-Kang.(2022).Active DNA demethylation in plants: 20 years of discovery and beyond.Journal of Integrative Plant Biology,64(12).
MLA
Zhang, Heng,et al."Active DNA demethylation in plants: 20 years of discovery and beyond".Journal of Integrative Plant Biology 64.12(2022).
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