| Title | Active DNA demethylation in plants: 20 years of discovery and beyond |
| Author | |
| Corresponding Author | Zhang, Heng; Gong, Zhizhong; Zhu, Jian-Kang |
| Publication Years | 2022-12-01
|
| DOI | |
| Source Title | |
| ISSN | 1672-9072
|
| EISSN | 1744-7909
|
| Volume | 64Issue:12 |
| Abstract | Maintaining proper DNA methylation levels in the genome requires active demethylation of DNA. However, removing the methyl group from a modified cytosine is chemically difficult and therefore, the underlying mechanism of demethylation had remained unclear for many years. The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation. In the 20 years since ROS1 was discovered, our understanding of this active DNA demethylation pathway, as well as its regulation and biological functions in plants, has greatly expanded. These exciting developments have laid the groundwork for further dissecting the regulatory mechanisms of active DNA demethylation, with potential applications in epigenome editing to facilitate crop breeding and gene therapy. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | [31922008]
; [XDB27040108]
; [X20200101]
; [2021YFA1300401]
|
| WOS Research Area | Biochemistry & Molecular Biology
; Plant Sciences
|
| WOS Subject | Biochemistry & Molecular Biology
; Plant Sciences
|
| WOS Accession No | WOS:000905780800002
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:1
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/425166 |
| Department | Institute of Advanced Biotechnology 生命科学学院 |
| Affiliation | 1.Chinese Acad Sci, Shanghai Ctr Plant Stress Biol, Ctr Excellence Mol Plant Sci, State Key Lab Mol Plant Genet, Shanghai 200032, Peoples R China 2.China Agr Univ, Coll Biol Sci, State Key Lab Plant Physiol & Biochem, Beijing 100193, Peoples R China 3.Hebei Univ, Inst Life Sci & Green Dev, Sch Life Sci, Baoding 071002, Peoples R China 4.Southern Univ Sci & Technol, Inst Adv Biotechnol, Sch Life Sci, Shenzhen 518055, Peoples R China |
| Corresponding Author Affilication | Institute of Advanced Biotechnology; School of Life Sciences |
| Recommended Citation GB/T 7714 |
Zhang, Heng,Gong, Zhizhong,Zhu, Jian-Kang. Active DNA demethylation in plants: 20 years of discovery and beyond[J]. Journal of Integrative Plant Biology,2022,64(12).
|
| APA |
Zhang, Heng,Gong, Zhizhong,&Zhu, Jian-Kang.(2022).Active DNA demethylation in plants: 20 years of discovery and beyond.Journal of Integrative Plant Biology,64(12).
|
| MLA |
Zhang, Heng,et al."Active DNA demethylation in plants: 20 years of discovery and beyond".Journal of Integrative Plant Biology 64.12(2022).
|
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