| Title | Green Synthesis of Liquid Metal-Doped Carbon Dots for Treating Multidrug-Resistant Gram-Negative Bacteria |
| Author | |
| Corresponding Author | Zhang, Wei; Jiang, Xingyu |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 2701-0198
|
| Abstract | Global emergence of multidrug-resistant (MDR) gram-negative bacteria triggers severe infections that result in an epidemic. It is urgent to discover novel classes of antibacterial agents. Here, a green route for synthesizing polyethylene glycol-based carbon dots (PEG-CDs) doped with liquid metal (LM-Cdots) via a solvent-free system is presented. LM-Cdots synthesized via ultrasound exhibit great antibacterial activity against gram-negative bacteria (E. coli, P. aeruginosa, K. pneumoniae, and A. baumannii) and their multidrug-resistant (MDR) clinical isolates. In the in vitro antibacterial test with MDR K. pneumoniae, LM-Cdots show an extremely low minimum inhibition concentration (MIC) of 0.63 mu g mL(-1). Compared to naked PEG-CDs, the MIC is improved by 1000 times. In vivo results reveal that LM-Cdots can accelerate wound healing with low biotoxicity and inflammation. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Key R&D Program of China[2018 YFA0902600]
; National Natural Science Foundation of China["21535001","81730051","32071390"]
; Shenzhen Science and Technology Program[KQTD20190929172743294]
; Shenzhen Key Laboratory of Smart Healthcare Engineering[ZDSYS20200811144003009]
|
| WOS Research Area | Materials Science
|
| WOS Subject | Materials Science, Biomaterials
|
| WOS Accession No | WOS:000913300500001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/425267 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, 11 Zhongguancun Beiyitiao, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, 1088 Xueyuan Rd, Shenzhen 518055, Guangdong, Peoples R China |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Bi, Shunchao,Hang, Chen,Qi, Jie,et al. Green Synthesis of Liquid Metal-Doped Carbon Dots for Treating Multidrug-Resistant Gram-Negative Bacteria[J]. Advanced Biology,2023.
|
| APA |
Bi, Shunchao,Hang, Chen,Qi, Jie,Zhang, Wei,&Jiang, Xingyu.(2023).Green Synthesis of Liquid Metal-Doped Carbon Dots for Treating Multidrug-Resistant Gram-Negative Bacteria.Advanced Biology.
|
| MLA |
Bi, Shunchao,et al."Green Synthesis of Liquid Metal-Doped Carbon Dots for Treating Multidrug-Resistant Gram-Negative Bacteria".Advanced Biology (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
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