| Title | A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue |
| Author | |
| Corresponding Author | Sun, Feifei; Zhang, Licheng; Tang, Peifu; Wu, Decheng |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 0935-9648
|
| EISSN | 1521-4095
|
| Abstract | Death happening due to massive hemorrhage has been involved in military conflicts, traffic accidents, and surgical injuries of various human disasters. Achieving rapid and effective hemostasis to save lives is crucial in urgent massive bleeding situations. Herein, a covalent cross-linked AG-PEG glue based on extracellular matrix-like amino-gelatin (AG) and PEG derivatives is developed. The AG-PEG glue gelatinizes fast and exhibits firm and indiscriminate close adhesion with various moist tissues upon being dosed. The formed glue establishes an adhesive and robust barrier to seal the arterial, hepatic, and cardiac hemorrhagic wounds, enabling it to withstand up to 380 mmHg blood pressure in comparison with normal systolic blood pressure of 60-180 mmHg. Remarkably, massive bleeding from a pig cardiac penetrating hole with 6 mm diameter is effectively stopped using the glue within 60 s. Postoperative indexes of the treated pig gradually recover and the cardiac wounds regrow significantly at 14 days. Possessing on-demand solubility, self-gelling, and rapid degradability, the AG-PEG glue may provide a fascinating stop-bleeding approach for clinical hemostasis and emergency rescue. |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | Corresponding
|
| Funding Project | National Natural Science Foundation of China["21935011~","21725403"]
; Youth Project of Beijing Municipal Natural Science Foundation[2214080]
; Shenzhen Science and Technology Innovation Commission[KQTD20200820113012029]
|
| WOS Research Area | Chemistry
; Science & Technology - Other Topics
; Materials Science
; Physics
|
| WOS Subject | Chemistry, Multidisciplinary
; Chemistry, Physical
; Nanoscience & Nanotechnology
; Materials Science, Multidisciplinary
; Physics, Applied
; Physics, Condensed Matter
|
| WOS Accession No | WOS:000915382700001
|
| Publisher | |
| ESI Research Field | MATERIALS SCIENCE
|
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/430739 |
| Department | Department of Biomedical Engineering |
| Affiliation | 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Orthoped Sports Med & Rehabil, Sr Dept Orthoped, Beijing 100853, Peoples R China 4.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Ultrasound, Beijing 100853, Peoples R China 6.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Peoples R China |
| Corresponding Author Affilication | Department of Biomedical Engineering |
| Recommended Citation GB/T 7714 |
Wang, Hufei,Cheng, Junyao,Sun, Feifei,et al. A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue[J]. ADVANCED MATERIALS,2023.
|
| APA |
Wang, Hufei.,Cheng, Junyao.,Sun, Feifei.,Dou, Xueyu.,Liu, Jianheng.,...&Wu, Decheng.(2023).A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue.ADVANCED MATERIALS.
|
| MLA |
Wang, Hufei,et al."A Super Tough, Rapidly Biodegradable, Ultrafast Hemostatic Bioglue".ADVANCED MATERIALS (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
; 
Edit Comment