中文版 | English
Title

Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients

Author
Corresponding AuthorYin, Da
Publication Years
2023-01-12
DOI
Source Title
EISSN
1475-2840
Volume22Issue:1
Abstract
Background Hypertension is a leading risk of coronary artery disease (CAD). Triglyceride glucose index (TyG) is a surrogate of insulin resistance (IR). Few studies explore the association between TyG and the incidence of obstructive CAD (OCAD) in hypertensive patients. Methods We retrospectively screened 1841 hypertensive subjects who were free of a history of CAD and underwent coronary computed tomography angiography (CCTA) because of chest pain. TyG index was calculated as ln (fasting TG [mg/dL] * fasting glucose [mg/dL]/2). The outcome of this research was OCAD, which was defined as the presence of diameter stenosis >= 50% in any of the four major epicardial coronary arteries detected on CCTA. Results A total of 310 (16.8%) patients developed obstructive CAD. The restricted cubic spline (RCS) analysis showed a J-shaped relationship between TyG and OCAD and the OR for OCAD increased as the TyG rose over 8.61 (OR perSD) 1.64, 95% CI 1.13-2.54, p = 0.008). After full adjustments for confounding covariates, patients with TyG index in tertile 3 (T3) had 2.12 times (95% CI 1.80 to 3.81) and in T2 had 2.01 times (95% CI 1.40 to 2.88) as high as the risk of OCAD compared with patients in T1 (p for trend = 0.001). When regarding TyG as a continuous variable, 1-SD increase elevated 49% (OR (95%CI), 1.49 (1.30-1.74)) risk of obstructive CAD (p = 0.007). This positive effect was still consistent across the subgroups (p for interaction > 0.05). Conclusion TyG index was associated with the incidence of obstructive CAD in hypertensive patients.
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Language
English
SUSTech Authorship
Corresponding
WOS Research Area
Cardiovascular System & Cardiology ; Endocrinology & Metabolism
WOS Subject
Cardiac & Cardiovascular Systems ; Endocrinology & Metabolism
WOS Accession No
WOS:000913512400002
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:3
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/430764
DepartmentShenzhen People's Hospital
Affiliation
1.Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Liaoning, Peoples R China
2.Dalian Univ, Affiliated Zhongshan Hosp, Dept Cardiol, Dalian, Liaoning, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Cardiol, 1017 Dongmen North Rd, Shenzhen, Peoples R China
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Pan, Weili,Ren, Yongkui,Yang, Fan,et al. Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients[J]. CARDIOVASCULAR DIABETOLOGY,2023,22(1).
APA
Pan, Weili,Ren, Yongkui,Yang, Fan,Wang, Minxian,Li, Xinsheng,&Yin, Da.(2023).Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients.CARDIOVASCULAR DIABETOLOGY,22(1).
MLA
Pan, Weili,et al."Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients".CARDIOVASCULAR DIABETOLOGY 22.1(2023).
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