Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment

Ma, Hualin1; Peng, Jingwen2; Zhang, Jianing2; Pan, Li2; Ouyang, Jiayi2; Li, Zimu2; Guo, Baochun1; Wang, Zhen1; Xu, Ying3; Lian, Daizheng4; Zeng, Xiaowei2

2023

10.3390/pharmaceutics15010015

PHARMACEUTICS   Impact Factor & Quartile

1999-4923

Polydopamine (PDA) is a natural melanin derived from marine mussels that has good biocompatibility, biodegradability, and photothermal conversion ability. As a new coating material, it offers a novel way to modify the surface of various substances. The drug loading capacity and encapsulation efficiency of PDA are greatly improved via the use of mesoporous materials. The abundant pore canals on mesoporous polydopamine (MPDA) exhibit a uniquely large surface area, which provides a structural basis for drug delivery. In this review, we systematically summarized the characteristics and manufacturing process of MPDA, introduced its application in the diagnosis and treatment of cancer, and discussed the existing problems in its development and clinical application. This comprehensive review will facilitate further research on MPDA in the fields of medicine including cancer therapy, materials science, and biology.

nanomedicine mesoporous polydopamine polymerization mechanism cancer diagnosis cancer treatment

SCI

English

First ; Corresponding

Pharmacology & Pharmacy

Pharmacology & Pharmacy

WOS:000916430200001

MDPI

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Nephrol, Shenzhen 518020, Peoples R China
2.Sun Yat sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Hematol, Shenzhen 518020, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Radiat Onco, Shenzhen 518020, Peoples R China

Ma, Hualin,Peng, Jingwen,Zhang, Jianing,et al. Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment[J]. PHARMACEUTICS,2023,15(1).

Ma, Hualin.,Peng, Jingwen.,Zhang, Jianing.,Pan, Li.,Ouyang, Jiayi.,...&Zeng, Xiaowei.(2023).Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment.PHARMACEUTICS,15(1).

Ma, Hualin,et al."Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment".PHARMACEUTICS 15.1(2023).