Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and perception

Li, Xiaoyun1; Yao, Junjie1; Lin, Xinxin1; Chen, Shengxiong2; Jin, Richu3,4; Peng, Weiwei1

2023-03-01

10.1016/j.clinph.2022.12.009

CLINICAL NEUROPHYSIOLOGY   Impact Factor & Quartile

1388-2457

1872-8952

Objective: The dorsolateral prefrontal cortex (DLPFC) has been increasingly used as a neuromodulatory target in pain management. Transcranial random noise stimulation (tRNS) was shown to effectively ele-vate cortical excitability. Hence, this study aimed to characterize how tRNS over the left DLPFC affects pain expectation and perception, as well as the efficacy of conditioned-pain modulation (CPM) that reflects the function of the endogenous pain-inhibitory pathway. Methods: Using a randomized, double-blinded, and sham-controlled design, healthy participants were randomly recruited to receive tRNS with a direct current offset or sham stimulation. Their expectations and perceptions of painful electrocutaneous stimuli, as well as CPM efficacy were assessed before, imme-diately after, and 30 min after tRNS. Results: Compared with sham stimulation, perceived-pain ratings to the painful stimuli, and expected -pain ratings before painful stimuli, attenuated immediately after tRNS, whereas this analgesic effect was ineffective 30 min after tRNS. Importantly, the immediate analgesia induced by tRNS could be accounted for by tRNS effect on attenuating expected-pain ratings before certain painful stimuli. However, CPM efficacy was not significantly affected by tRNS. Conclusions: These results demonstrate analgesia immediately after applying tRNS over the left DLPFC. Significance: This study provides evidence for analgesia of DLPFC-tRNS on an experimental pain model.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Transcranial random noise stimulation (tRNS) Dorsolateral prefrontal cortex (DLPFC) Pain perception Pain expectation Conditioned pain modulation (CPM)

SCI

English

Corresponding

Ministry of Science and Technology of China[2022ZD0206400] ; National Natural Science Foundation of China["32271105","32200900","62101236"] ; Shenzhen Natural Science Fund[20200812113251002]

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:000919660700001

ELSEVIER IRELAND LTD

NEUROSCIENCE & BEHAVIOR

2-s2.0-85146002951

Web of Science

1.Shenzhen Univ, Sch Psychol, Shenzhen, Guangdong, Peoples R China
2.Shenzhen Prevent & Treatment Ctr Occupat Dis, Med Rehabil Ctr, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Dept Comp Sci & Engn, Shenzhen, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Dept Comp Sci & Engn, Xueyuan Ave 1088, Shenzhen 518055, Peoples R China

Li, Xiaoyun,Yao, Junjie,Lin, Xinxin,et al. Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and perception[J]. CLINICAL NEUROPHYSIOLOGY,2023,147:1-10.

Li, Xiaoyun,Yao, Junjie,Lin, Xinxin,Chen, Shengxiong,Jin, Richu,&Peng, Weiwei.(2023).Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and perception.CLINICAL NEUROPHYSIOLOGY,147,1-10.

Li, Xiaoyun,et al."Transcranial random noise stimulation over the left dorsolateral prefrontal cortex attenuates pain expectation and perception".CLINICAL NEUROPHYSIOLOGY 147(2023):1-10.