In Vitro Cytocompatibility and Anti-biofilm Properties of Electrodeposited Ternary-Ion-Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications

Bian, Anqi1; Jia, Fenghuan1; Wu, Zongze6; Li, Meiyu1; Yang, Hao3; Huang, Xiao4; Xie, Lei2; Qiao, Haixia1; Lin, He5; Huang, Yong1,2

2023-01-27

10.1002/slct.202203683

ChemistrySelect   Impact Factor & Quartile

2365-6549

Currently, there is a growing market for implant coatings that efficiently ward off bacterial infections while aiding in clinical osseointegration. Due to its potential to have a number of functions (including osteogenic activity and antibacterial activity) for bone implantation, the hydroxyapatite (HA) coating doped with multiple ions has drawn a lot of attention. In this study, innovative nanohydroxyapatite coatings containing simultaneous Sr2+, Mn2+, and Ag+ substitutions (MnSrAgHA) were devised and effectively electrodedeposited on pure titanium. That is, the antibacterial ability of MnSrAgHA was enhanced by Ag+, Sr2+ and Mn2+ not only can balance the potential cytotoxicity of Ag+, but also can improve the bone repair rate of composite materials. Some experimental (FE-SEM, XPS and EDS, etc.) results about the characterization show that Sr2+, Mn2+ and Ag+ can uniformly combine into the HA lattice to form the SrMnAgHA coating. The MnSrAgHA coating surface was rather dense, with numerous needle-like or flower cluster crystals, and the coating thickness is approximately 10 mu m. Moreover, compared with other coatings (HA, AgHA and SrAgHA), the MnSrAgHA coating had a smaller roughness and higher contact angle. However, the contact angle of MnSrAgHA was still within the hydrophilic range. Staphylococcus aureus growth was inhibited by the MnSrAgHA coating, and the antibacterial rate was almost 100 %. The MnSrAgHA coating dramatically enhanced cell proliferation, adhesion, and differentiation abilities, according to in-vitro cell culture studies. As expected, osteoblasts are not significantly cytotoxic by the MnSrAgHA coating. Due to its adaptability, the multi-element co-doped HA coating (MnSrAgHA) offers enormous clinical application potential in anti-infective repair.

Antibacterial properties Cytocompatibility Hydroxyapatite Multi-ion doped Orthopaedic applications

SCI

English

Corresponding

Research Fund for Nature Science Foundation of Hebei province["H2020405015","H2021405041"] ; Science and Technology Research Project of Hebei Higher Education Institutions["JYT2022017","JYT2022006"] ; [ZD2021007] ; [QN2020247]

Chemistry

Chemistry, Multidisciplinary

WOS:000919816900001

WILEY-V C H VERLAG GMBH

Web of Science

1.Hebei North Univ, Coll Lab Med, Key Lab Biomed Mat Zhangjiakou, Zhangjiakou 075000, Peoples R China
2.Univ Elect Sci & Technol China, Sch Med, Chengdu 610054, Peoples R China
3.Minist Educ, Wuhan Inst Technol, Key Lab Green Chem Proc, Wuhan 430205, Peoples R China
4.Guangxi Univ Sci & Technol, Sch Phys Educ, Liuzhou 545006, Peoples R China
5.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China
6.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Interve, Shenzhen 518020, Peoples R China

Bian, Anqi,Jia, Fenghuan,Wu, Zongze,et al. In Vitro Cytocompatibility and Anti-biofilm Properties of Electrodeposited Ternary-Ion-Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications[J]. ChemistrySelect,2023,8(4).

Bian, Anqi.,Jia, Fenghuan.,Wu, Zongze.,Li, Meiyu.,Yang, Hao.,...&Huang, Yong.(2023).In Vitro Cytocompatibility and Anti-biofilm Properties of Electrodeposited Ternary-Ion-Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications.ChemistrySelect,8(4).

Bian, Anqi,et al."In Vitro Cytocompatibility and Anti-biofilm Properties of Electrodeposited Ternary-Ion-Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications".ChemistrySelect 8.4(2023).