中文版 | English
Title

Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway

Author
Corresponding AuthorDu,Xiao
Publication Years
2023-04-01
DOI
Source Title
ISSN
1878-5352
EISSN
1878-5379
Volume16Issue:4
Abstract
Yin-Chen, which belongs to the Asteraceae family and the genus Artemisia, is among the most abundantly used traditional medicines in China for the treatment of hepatitis and bilious disorder. Herein, five undescribed plant-derived bisphenols, capillarisenols A–E (13, 15, 25, 29, 31), and one undescribed phenolic compound (32), together with 32 known phenolic compounds (1–12, 14, 16–24, 26–28, 30, 33–38), were isolated and identified based on spectroscopic evidence from aerial parts of Artemisia capillaris Thunb. Capillarisenols A–E are the type of bisphenols firstly isolated from this plant. The plausible biogenetic pathway of new compounds was also proposed. In addition, the potential anti-hepatoma effects on Huh7 and HepG2 cell lines of all isolated compounds were evaluated in vitro. Capillarisenol C (25) showed significant anti-hepatoma activity in Huh7 and HepG 2 cells, with IC values of 4.96 and 8.58 μM, better than the positive control drug (Lenvatinib). This study provided phytochemical evidence for further development and utilisation of A. capillaris in health products.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
National Natural Science Foundation of China["81503221","81903760"] ; Natural Science Foundation of Guangdong Province["2017A030313659","2021A1515220185"] ; Shenzhen Fundamental Research and Discipline Layout Project["JCYJ20170413093108233","JCYJ20190806151816859","JCYJ20190806153401647","JCYJ20220818102609021"]
WOS Research Area
Chemistry
WOS Subject
Chemistry, Multidisciplinary
WOS Accession No
WOS:000963245600001
Publisher
Scopus EID
2-s2.0-85146608388
Data Source
Scopus
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/442596
DepartmentShenzhen People's Hospital
Affiliation
1.Center Lab of Longhua Branch and Department of Infectious Disease,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,So uthern University of Science and Technology),Shenzhen,Guangdong Province,518020,China
2.Department of pathology (Longhua Branch),Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong Province,518120,China
3.College of pharmacy,Gansu University of Chinese Medicine,Lanzhou,Gansu Province,730000,China
4.Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan,Guangdong Province,528241,China
5.College of Pharmacy,School of Medicine,Hangzhou Normal University,Hangzhou,Zhejiang Province,311121,China
6.China Resources Sanjiu Medical & Pharmaceutical Co.,Ltd.,Shenzhen,Guangdong Province,518110,China
7.Guangdong Provincial Key Laboratory of Regional Immunity and Diseases,Medicine School of Shenzhen University,Shenzhen,Guangdong Province,518037,China
First Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Ge,Lanlan,Xie,Qiujie,Wei,Xiaofang,et al. Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway[J]. Arabian Journal of Chemistry,2023,16(4).
APA
Ge,Lanlan.,Xie,Qiujie.,Wei,Xiaofang.,Li,Yangfang.,Shen,Wanying.,...&Zeng,Xiaobin.(2023).Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway.Arabian Journal of Chemistry,16(4).
MLA
Ge,Lanlan,et al."Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway".Arabian Journal of Chemistry 16.4(2023).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Export to Excel
Export to Csv
Altmetrics Score
Google Scholar
Similar articles in Google Scholar
[Ge,Lanlan]'s Articles
[Xie,Qiujie]'s Articles
[Wei,Xiaofang]'s Articles
Baidu Scholar
Similar articles in Baidu Scholar
[Ge,Lanlan]'s Articles
[Xie,Qiujie]'s Articles
[Wei,Xiaofang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ge,Lanlan]'s Articles
[Xie,Qiujie]'s Articles
[Wei,Xiaofang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.