Title | Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway |
Author | |
Corresponding Author | Du,Xiao |
Publication Years | 2023-04-01
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DOI | |
Source Title | |
ISSN | 1878-5352
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EISSN | 1878-5379
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Volume | 16Issue:4 |
Abstract | Yin-Chen, which belongs to the Asteraceae family and the genus Artemisia, is among the most abundantly used traditional medicines in China for the treatment of hepatitis and bilious disorder. Herein, five undescribed plant-derived bisphenols, capillarisenols A–E (13, 15, 25, 29, 31), and one undescribed phenolic compound (32), together with 32 known phenolic compounds (1–12, 14, 16–24, 26–28, 30, 33–38), were isolated and identified based on spectroscopic evidence from aerial parts of Artemisia capillaris Thunb. Capillarisenols A–E are the type of bisphenols firstly isolated from this plant. The plausible biogenetic pathway of new compounds was also proposed. In addition, the potential anti-hepatoma effects on Huh7 and HepG2 cell lines of all isolated compounds were evaluated in vitro. Capillarisenol C (25) showed significant anti-hepatoma activity in Huh7 and HepG 2 cells, with IC values of 4.96 and 8.58 μM, better than the positive control drug (Lenvatinib). This study provided phytochemical evidence for further development and utilisation of A. capillaris in health products. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
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SUSTech Authorship | Others
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Funding Project | National Natural Science Foundation of China["81503221","81903760"]
; Natural Science Foundation of Guangdong Province["2017A030313659","2021A1515220185"]
; Shenzhen Fundamental Research and Discipline Layout Project["JCYJ20170413093108233","JCYJ20190806151816859","JCYJ20190806153401647","JCYJ20220818102609021"]
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WOS Research Area | Chemistry
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WOS Subject | Chemistry, Multidisciplinary
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WOS Accession No | WOS:000963245600001
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Publisher | |
Scopus EID | 2-s2.0-85146608388
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/442596 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Center Lab of Longhua Branch and Department of Infectious Disease,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,So uthern University of Science and Technology),Shenzhen,Guangdong Province,518020,China 2.Department of pathology (Longhua Branch),Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University; The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong Province,518120,China 3.College of pharmacy,Gansu University of Chinese Medicine,Lanzhou,Gansu Province,730000,China 4.Guangdong Yifang Pharmaceutical Co.,Ltd.,Foshan,Guangdong Province,528241,China 5.College of Pharmacy,School of Medicine,Hangzhou Normal University,Hangzhou,Zhejiang Province,311121,China 6.China Resources Sanjiu Medical & Pharmaceutical Co.,Ltd.,Shenzhen,Guangdong Province,518110,China 7.Guangdong Provincial Key Laboratory of Regional Immunity and Diseases,Medicine School of Shenzhen University,Shenzhen,Guangdong Province,518037,China |
First Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Ge,Lanlan,Xie,Qiujie,Wei,Xiaofang,et al. Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway[J]. Arabian Journal of Chemistry,2023,16(4).
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APA |
Ge,Lanlan.,Xie,Qiujie.,Wei,Xiaofang.,Li,Yangfang.,Shen,Wanying.,...&Zeng,Xiaobin.(2023).Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway.Arabian Journal of Chemistry,16(4).
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MLA |
Ge,Lanlan,et al."Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway".Arabian Journal of Chemistry 16.4(2023).
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