Polydopamine-guarded metal-organic frameworks as co-delivery systems for starvation-assisted chemo-photothermal therapy
Cutting off glucose provision by glucose oxidase (GOx) to famish tumors can be an assistance with chemotherapy to eliminate cancer cells. Co-encapsulation of GOx and chemotherapeutics (doxorubicin) within pH-sensitive metal-organic frameworks (MOFs) could disorder metabolic pathways of cancer cells and generate excessive intracellular reactive oxygen species (ROS), together. To prevent premature leach of GOx from the porous channels of MOFs, polydopamine (PDA) was deposited on the surface of MOFs, which endowed the delivery system with photothermal conversion ability. Our nanoscaled co-delivery system (denoted as DGZPNs) remains stable with low amount of drug leakage under simulated physiological conditions in vitro and internal environment, while they are triggered to release doxorubicin (DOX) and GOx in acid tumor microenvironment and at high temperature for reinforced chemotherapy. NIR laser irradiation also activates superior photothermal conversion efficiency of PDA (36.9 %) to initiate hyperthermia to ablate tumor tissue. After being phagocytized by 4 T1 cells (breast cancer cells), the DGZPNs delivery system showed a superior therapeutic efficacy with a tumor growth inhibition of 88.9 ± 6.6 % under NIR irradiation, which indicated that the starvation-assisted chemo-photothermal therapy prompts the significant advance of synergistic therapy in a parallelly controlled mode.
National Natural Science Foundation of China["22003038","81922037","11575107"] ; Shanghai University-Uni-versal Medical Imaging Diagnostic Research Foundation[19H00100] ; Shanghai Biomedical Science and Technology Support Project ; Program for Changjiang Scholars and Innovative Research Team in University[IRT13078]
|WOS Research Area|
Materials Science, Biomaterials
|WOS Accession No|
Cited Times [WOS]:2
|Document Type||Journal Article|
|Department||Shenzhen People's Hospital|
1.Institution of Nanochemistry and Nanobiology,School of Environmental and Chemical Engineering,Shanghai University,Shanghai,200444,China
2.School of Medicine,Shanghai University,Shanghai,200444,China
3.Key Laboratory of Tropical Translation Medicine of Ministry of Education,Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs,School of Pharmacy,Hainan Medical University,Haikou,571199,China
4.The First Affiliated Hospital (Shenzhen People's Hospital),Southern University of Science and Technology,Shenzhen,518055,China
Zhan，Lin,Yin，Xuelian,Zhang，Yuxi,et al. Polydopamine-guarded metal-organic frameworks as co-delivery systems for starvation-assisted chemo-photothermal therapy[J]. Biomaterials Advances,2023,146.
Zhan，Lin.,Yin，Xuelian.,Zhang，Yuxi.,Ju，Jiale.,Wu，Yinghua.,...&Wang，Yanlin.(2023).Polydopamine-guarded metal-organic frameworks as co-delivery systems for starvation-assisted chemo-photothermal therapy.Biomaterials Advances,146.
Zhan，Lin,et al."Polydopamine-guarded metal-organic frameworks as co-delivery systems for starvation-assisted chemo-photothermal therapy".Biomaterials Advances 146(2023).
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