中文版 | English
Title

Exosome nanovesicles: A potential carrier for therapeutic delivery

Author
Corresponding AuthorChavda,Vivek P.
Publication Years
2023-04-01
DOI
Source Title
ISSN
1748-0132
EISSN
1878-044X
Volume49
Abstract
Exosomes are small nanosized biovesicles that form when multivesicular bodies and the plasma membrane fuse and are released into the surrounding body fluids. They are best known for their multifunction in mediating intercellular communication by transferring various biomolecules, including DNA, RNAs, proteins, and lipids, in a short- and long-distance manner and have been identified as health and disease messengers. Importantly, exosomes are necessary for various physiological processes in health and disease. The generation of exosomes depends on the status of the disease, which usually exhibits opposite roles by inducing enhanced cellular stress and damage. Recently, exosome-based nanotechnologies have provided unprecedented opportunities to boost the developments of exosome-related biology, chemistry, pathology, and therapeutics in different diseases based on their unique structural/compositional/morphological characteristics for next-generation nanomedicines. Herein, we provide a comprehensive overview of the recent advances in exosome nanotechnology research, including their classification, isolation and preparation, constitution, biological function, and nanobiomedical applications in disease treatment and diagnosis. Furthermore, future prospects were also concluded. This review will provide more inspiration for promoting the development of exosome-based advanced theranostic nanoplatforms and nanotechnology.
Keywords
URL[Source Record]
Language
English
SUSTech Authorship
Others
Scopus EID
2-s2.0-85147606099
Data Source
Scopus
Citation statistics
Cited Times [WOS]:1
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/449858
DepartmentShenzhen People's Hospital
Affiliation
1.Department of Pharmaceutics and Pharmaceutical Technology,L M College of Pharmacy,Ahmedabad,380009,India
2.Department of Pharmaceutical Sciences and Technology,Institute of Chemical Technology,Mumbai,400 019,India
3.Department of Pharmaceutics,National Institute of Pharmaceutical Education and Research,Hajipur,Bihar,844102,India
4.University of British Columbia,Pharmaceutical Sciences Building,Vancouver,2405 Wesbrook Mall,V6T1Z3,United States
5.School of Pharmacy,Queen's University Belfast,Belfast,97 Lisburn Road,BT9 7BL,United Kingdom
6.Department of Pharmaceutics,Manipal College of Pharmaceutical Sciences,Manipal Academy of Higher Education,Udupi,Manipal, Karnataka,576 104,India
7.Department of Radiation Oncology,the Second Clinical Medical College of Jinan University,1st Affiliated Hospital of Southern University of Science and Technology,Shenzhen People's Hospital,Shenzhen,518020,China
8.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,Sweden
9.Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and Institute for Advanced Study,The Hong Kong University of Science and Technology,Kowloon,Clear Water Bay,999077,Hong Kong
Recommended Citation
GB/T 7714
Chavda,Vivek P.,Pandya,Anjali,Kumar,Lalit,et al. Exosome nanovesicles: A potential carrier for therapeutic delivery[J]. Nano Today,2023,49.
APA
Chavda,Vivek P..,Pandya,Anjali.,Kumar,Lalit.,Raval,Nidhi.,Vora,Lalitkumar K..,...&Tang,Ben Zhong.(2023).Exosome nanovesicles: A potential carrier for therapeutic delivery.Nano Today,49.
MLA
Chavda,Vivek P.,et al."Exosome nanovesicles: A potential carrier for therapeutic delivery".Nano Today 49(2023).
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