Title | Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses |
Author | |
Corresponding Author | Geng,Qingshan |
Publication Years | 2023-12-01
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DOI | |
Source Title | |
EISSN | 1479-5876
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Volume | 21Issue:1 |
Abstract | Background: Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations of genetically determined sleep durations with MetS and its five components (i.e., central obesity, high blood pressure, dyslipidemia, hypertriglyceridemia, and hyperglycemia) among a group of elderly population. Methods: In 335,727 participants of White British from the UK Biobank, linear Mendelian randomization (MR) methods were first employed to examine the causal association of genetically predicted continuous sleep duration with MetS and its each component. Nonlinear MR analyses were performed to determine the nonlinearity of these associations. The causal associations of short and long sleep duration with MetS and its components were further assessed by using genetic variants that associated with short (≤ 6 h) and long sleep (≥ 9 h) durations. Results: Linear MR analyses demonstrated that genetically predicted 1-h longer sleep duration was associated with a 13% lower risk of MetS, a 30% lower risk of central obesity, and a 26% lower risk of hyperglycemia. Non-linear MR analyses provided evidence for non-linear associations of genetically predicted sleep duration with MetS and its five components (all P values < 0.008). Genetically predicted short sleep duration was moderately associated with MetS and its four components, including central obesity, dyslipidemia, hypertriglyceridemia, and hyperglycemia (all P values < 0.002), whereas genetically long sleep duration was not associated with MetS and any of its components. Conclusions: Genetically predicted short sleep duration, but not genetically predicted long sleep duration, is a potentially causal risk factor for MetS. Graphical Abstract: [Figure not available: see fulltext.] |
Keywords | |
URL | [Source Record] |
Language | English
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SUSTech Authorship | Corresponding
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Scopus EID | 2-s2.0-85147460615
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Data Source | Scopus
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Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/466490 |
Department | Shenzhen People's Hospital |
Affiliation | 1.Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,102 Zhongshan Road, Guangdong,China 2.Li Chiu Kong Family Sleep Assessment Unit,Department of Psychiatry,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,Hong Kong 3.Department of Endocrinology,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong,China 4.The Affiliated Hospital of Kunming University of Science and Technology,The First People’s Hospital of Yunnan Province,Kunming,Yunnan,China 5.The First School of Clinical Medicine,Southern Medical University,Guangzhou,China 6.Department of Big Data in Health Science,Zhejiang University School of Public Health,Hangzhou,China 7.Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,China 8.Department of Medical Sciences,Uppsala University,Uppsala,Sweden 9.Institute and Department of Endocrinology and Metabolism,Shanghai Ninth People’s Hospital,Shanghai JiaoTong University School of Medicine,Shanghai,China 10.Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,China 11.Center for Sleep and Circadian Medicine,The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou,36 Mingxin Road, Guangdong,China 12.Department of Geriatrics,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,Shenzhen,Guangdong,China 13.Department of Geriatrics,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,China 14.Department of Cardiology,Life Science Center,Heart Center,The First Affiliated Hospital of Xinxiang Medical University,Weihui,Henan,China |
Corresponding Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Liang,Yannis Yan,Chen,Jie,Peng,Miaoguan,et al. Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses[J]. Journal of Translational Medicine,2023,21(1).
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APA |
Liang,Yannis Yan.,Chen,Jie.,Peng,Miaoguan.,Zhou,Jiajin.,Chen,Xinru.,...&Ai,Sizhi.(2023).Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses.Journal of Translational Medicine,21(1).
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MLA |
Liang,Yannis Yan,et al."Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses".Journal of Translational Medicine 21.1(2023).
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