Peptide-based inhibitors hold great promise as the broad-spectrum agents against coronavirus

Tang, Mingxing1,2,3; Zhang, Xin3; Huang, Yanhong1,3; Cheng, Wenxiang4; Qu, Jing5; Gui, Shuiqing6; Li, Liang3; Li, Shuo2

2023-01-19

10.3389/fmicb.2022.1093646

FRONTIERS IN MICROBIOLOGY   Impact Factor & Quartile

1664-302X

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS), and the recent SARS-CoV-2 are lethal coronaviruses (CoVs) that have caused dreadful epidemic or pandemic in a large region or globally. Infections of human respiratory systems and other important organs by these pathogenic viruses often results in high rates of morbidity and mortality. Efficient anti-viral drugs are needed. Herein, we firstly take SARS-CoV-2 as an example to present the molecular mechanism of CoV infection cycle, including the receptor binding, viral entry, intracellular replication, virion assembly, and release. Then according to their mode of action, we provide a summary of anti-viral peptides that have been reported in peer-reviewed publications. Even though CoVs can rapidly evolve to gain resistance to the conventional small molecule drugs, peptide-based inhibitors targeting various steps of CoV lifecycle remain a promising approach. Peptides can be continuously modified to improve their antiviral efficacy and spectrum along with the emergence of new viral variants.

SARS-CoV-2 viral infection spike protein anti-viral peptides host protease host receptors

SCI

English

Corresponding

Microbiology

Microbiology

WOS:000921691300001

FRONTIERS MEDIA SA

Web of Science

1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
2.Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Otolaryngol, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
4.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Translat Med Res & Dev, Shenzhen, Peoples R China
5.Shenzhen Ctr Dis Control & Prevent, Dept Pathogen Biol, Shenzhen, Peoples R China
6.Shenzhen Univ, Shenzhen Peoples Hosp 2, Dept Crit Care Med, Affiliated Hosp 1, Shenzhen, Peoples R China

Tang, Mingxing,Zhang, Xin,Huang, Yanhong,et al. Peptide-based inhibitors hold great promise as the broad-spectrum agents against coronavirus[J]. FRONTIERS IN MICROBIOLOGY,2023,13.

Tang, Mingxing.,Zhang, Xin.,Huang, Yanhong.,Cheng, Wenxiang.,Qu, Jing.,...&Li, Shuo.(2023).Peptide-based inhibitors hold great promise as the broad-spectrum agents against coronavirus.FRONTIERS IN MICROBIOLOGY,13.

Tang, Mingxing,et al."Peptide-based inhibitors hold great promise as the broad-spectrum agents against coronavirus".FRONTIERS IN MICROBIOLOGY 13(2023).