Smart Mitochondria-Specific Anchored Gold-based Nanosystem for Integration of Tumor Imaging and Treatment

Yin, Xuelian1,2; Zhan, Lin1; Ding, Lin3; Chen, Xuerui2; Zhang, Junfeng1; Li, Chenchen1,4; Zhang, Yuxi1; Khan, Murad4; Reis, Rui L.5; Wang, Yanli4

2023-02-01

10.1002/admt.202201929

Advanced Materials Technologies   Impact Factor & Quartile

2365-709X

Although recent advances have been made in improving the efficacy of photodynamic therapy, efficient therapeutic approaches based on reactive oxygen species (ROS) are needed, particularly mitochondria-specific targeting of nanomaterials that can alter the internal environment of organelles. Herein, we report the facile synthesis of mitochondria-specific anchored nano-complexes (AG-C-NP) comprised of a skeleton of gold and carbon atoms for cancer therapy. Compared to the effects of gold nanoclusters (Au NCs), AG-C-NP showed enhanced fluorescence imaging effects, which can be used for tumor monitoring. AG-C-NP targeted the mitochondria and increased ROS damage in cancer cells. After treatment with AG-C-NP, the tumor inhibition rate reached 70.94%, which was 25.98% and 36.91% higher than that of free doxorubicin (DOX) and gemcitabine (Gem), respectively. Studying the mechanism of AG-C-NP inhibiting cancer shows that AG-C-NP could promote tumor cells to produce excessive ROS by overexpressing P53 and increasing the number of apoptotic cancer cells, which was caused by overexpression of Caspase1 that was closely related to cell apoptosis. AG-C-NP is a promising anticancer drug that targets the mitochondria in vivo to trigger excessive ROS production in tumor cells and inhibit tumor growth.

fluorescence imaging mitochondria-specific anchored reactive oxygen species tumor targeting

SCI

English

Others

National Natural Science Foundation of China["21371115","22003038","81922037","11575107"] ; Shanghai University-Universal Medical Imaging Diagnostic Research Foundation[19H00100] ; Shanghai Biomedical Science and Technology Support Project[19441903600] ; Guangdong Basic and Applied Basic Research Foundation["2021A1515110657","2022A1515010056"] ; Shenzhen Science and Technology Program[RCBS20210609104513023]

Materials Science

Materials Science, Multidisciplinary

WOS:000922434100001

WILEY

Web of Science

1.Shanghai Univ, Sch Environm & Chem Engn, Shanghai 200444, Peoples R China
2.Shanghai Univ, Sch Med, Shanghai 200444, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen 518055, Peoples R China
4.Hainan Med Univ, Hainan Prov Key Lab Res & Dev Trop Herbs, Sch Pharm, Key Lab Trop Translat Med,Minist Educ Hainan Prov, Haikou 571199, Peoples R China
5.Univ Minho, Res Inst Biomat Biodegradables & Biomimet I3Bs, Headquarters European Inst Excellence Tissue Engn, Res Grp 3Bs, AvePk,Parque Ciencia &Tecnol,Zona Ind Gandra, P-4805017 Guimaraes, Portugal

Yin, Xuelian,Zhan, Lin,Ding, Lin,et al. Smart Mitochondria-Specific Anchored Gold-based Nanosystem for Integration of Tumor Imaging and Treatment[J]. Advanced Materials Technologies,2023.

Yin, Xuelian.,Zhan, Lin.,Ding, Lin.,Chen, Xuerui.,Zhang, Junfeng.,...&Wang, Yanli.(2023).Smart Mitochondria-Specific Anchored Gold-based Nanosystem for Integration of Tumor Imaging and Treatment.Advanced Materials Technologies.

Yin, Xuelian,et al."Smart Mitochondria-Specific Anchored Gold-based Nanosystem for Integration of Tumor Imaging and Treatment".Advanced Materials Technologies (2023).