中文版 | English
Title

Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities

Author
Corresponding AuthorYao, Jun; Wang, Li-sheng; Liang, Yu-jie
Publication Years
2023
DOI
Source Title
EISSN
2380-6761
Abstract
Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein replacement, and genome editing. In general, mRNA does not have the risk of being incorporated into the host genome and does not need to enter the nucleus for transfection, and it can be expressed even in nondividing cells. Therefore, mRNA-based therapeutics provide a promising strategy for clinical treatment. However, the efficient and safe delivery of mRNA remains a crucial constraint for the clinical application of mRNA therapeutics. Although the stability and tolerability of mRNA can be enhanced by directly retouching the mRNA structure, there is still an urgent need to improve the delivery of mRNA. Recently, significant progress has been made in nanobiotechnology, providing tools for developing mRNA nanocarriers. Nano-drug delivery system is directly used for loading, protecting, and releasing mRNA in the biological microenvironment and can be used to stimulate the translation of mRNA to develop effective intervention strategies. In the present review, we summarized the concept of emerging nanomaterials for mRNA delivery and the latest progress in enhancing the function of mRNA, primarily focusing on the role of exosomes in mRNA delivery. Moreover, we outlined its clinical applications so far. Finally, the key obstacles of mRNA nanocarriers are emphasized, and promising strategies to overcome these obstacles are proposed. Collectively, nano-design materials exert functions for specific mRNA applications, provide new perception for next-generation nanomaterials, and thus revolution of mRNA technology.
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
Science and Technology Innovation Committee of Shenzhen["JCYJ20200109150700942","CXFZ20211020164543006"] ; Shenzhen Clinical Research Center for Mental Disorders[20210617155253001] ; Guangdong Basic and Applied Basic Research Foundation[2020A1515011581] ; Key-Area Research and Development Program of Guangdong Province[2019B030335001] ; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK042] ; Shenzhen Science and Technology Projects["KCXFZ20211020164543006","JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ20210324113802006"]
WOS Research Area
Biotechnology & Applied Microbiology ; Engineering ; Pharmacology & Pharmacy
WOS Subject
Biotechnology & Applied Microbiology ; Engineering, Biomedical ; Pharmacology & Pharmacy
WOS Accession No
WOS:000922742000001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/475080
DepartmentShenzhen People's Hospital
南方科技大学第二附属医院
Affiliation
1.Jinan Univ, Shenzhen Peoples Hosp, Dept Gastroenterol, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
4.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China
5.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou, Peoples R China
6.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China
7.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China
8.Jinan Univ, Shenzhen Peoples Hosp, Dept Emergency, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
9.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen, Peoples R China
10.Jining Med Univ, Affiliated Hosp, Jining, Shandong, Peoples R China
First Author AffilicationShenzhen People's Hospital
Corresponding Author AffilicationShenzhen People's Hospital
Recommended Citation
GB/T 7714
Li, De-feng,Liu, Qi-song,Yang, Mei-feng,et al. Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities[J]. BIOENGINEERING & TRANSLATIONAL MEDICINE,2023.
APA
Li, De-feng.,Liu, Qi-song.,Yang, Mei-feng.,Xu, Hao-ming.,Zhu, Min-zheng.,...&Liang, Yu-jie.(2023).Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities.BIOENGINEERING & TRANSLATIONAL MEDICINE.
MLA
Li, De-feng,et al."Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities".BIOENGINEERING & TRANSLATIONAL MEDICINE (2023).
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