Title | Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities |
Author | |
Corresponding Author | Yao, Jun; Wang, Li-sheng; Liang, Yu-jie |
Publication Years | 2023
|
DOI | |
Source Title | |
EISSN | 2380-6761
|
Abstract | Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein replacement, and genome editing. In general, mRNA does not have the risk of being incorporated into the host genome and does not need to enter the nucleus for transfection, and it can be expressed even in nondividing cells. Therefore, mRNA-based therapeutics provide a promising strategy for clinical treatment. However, the efficient and safe delivery of mRNA remains a crucial constraint for the clinical application of mRNA therapeutics. Although the stability and tolerability of mRNA can be enhanced by directly retouching the mRNA structure, there is still an urgent need to improve the delivery of mRNA. Recently, significant progress has been made in nanobiotechnology, providing tools for developing mRNA nanocarriers. Nano-drug delivery system is directly used for loading, protecting, and releasing mRNA in the biological microenvironment and can be used to stimulate the translation of mRNA to develop effective intervention strategies. In the present review, we summarized the concept of emerging nanomaterials for mRNA delivery and the latest progress in enhancing the function of mRNA, primarily focusing on the role of exosomes in mRNA delivery. Moreover, we outlined its clinical applications so far. Finally, the key obstacles of mRNA nanocarriers are emphasized, and promising strategies to overcome these obstacles are proposed. Collectively, nano-design materials exert functions for specific mRNA applications, provide new perception for next-generation nanomaterials, and thus revolution of mRNA technology. |
Keywords | |
URL | [Source Record] |
Indexed By | |
Language | English
|
SUSTech Authorship | Corresponding
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Funding Project | Science and Technology Innovation Committee of Shenzhen["JCYJ20200109150700942","CXFZ20211020164543006"]
; Shenzhen Clinical Research Center for Mental Disorders[20210617155253001]
; Guangdong Basic and Applied Basic Research Foundation[2020A1515011581]
; Key-Area Research and Development Program of Guangdong Province[2019B030335001]
; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013]
; Shenzhen Key Medical Discipline Construction Fund[SZXK042]
; Shenzhen Science and Technology Projects["KCXFZ20211020164543006","JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ20210324113802006"]
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WOS Research Area | Biotechnology & Applied Microbiology
; Engineering
; Pharmacology & Pharmacy
|
WOS Subject | Biotechnology & Applied Microbiology
; Engineering, Biomedical
; Pharmacology & Pharmacy
|
WOS Accession No | WOS:000922742000001
|
Publisher | |
Data Source | Web of Science
|
Citation statistics |
Cited Times [WOS]:0
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Document Type | Journal Article |
Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/475080 |
Department | Shenzhen People's Hospital 南方科技大学第二附属医院 |
Affiliation | 1.Jinan Univ, Shenzhen Peoples Hosp, Dept Gastroenterol, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China 4.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen, Guangdong, Peoples R China 5.South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol & Hepatol, Guangzhou, Peoples R China 6.South China Univ Technol, Affiliated Hosp 2, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou, Guangdong, Peoples R China 7.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou, Guangdong, Peoples R China 8.Jinan Univ, Shenzhen Peoples Hosp, Dept Emergency, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China 9.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Dept Child & Adolescent Psychiat, Shenzhen, Peoples R China 10.Jining Med Univ, Affiliated Hosp, Jining, Shandong, Peoples R China |
First Author Affilication | Shenzhen People's Hospital |
Corresponding Author Affilication | Shenzhen People's Hospital |
Recommended Citation GB/T 7714 |
Li, De-feng,Liu, Qi-song,Yang, Mei-feng,et al. Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities[J]. BIOENGINEERING & TRANSLATIONAL MEDICINE,2023.
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APA |
Li, De-feng.,Liu, Qi-song.,Yang, Mei-feng.,Xu, Hao-ming.,Zhu, Min-zheng.,...&Liang, Yu-jie.(2023).Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities.BIOENGINEERING & TRANSLATIONAL MEDICINE.
|
MLA |
Li, De-feng,et al."Nanomaterials for mRNA-based Therapeutics: Challenges and Opportunities".BIOENGINEERING & TRANSLATIONAL MEDICINE (2023).
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