中文版 | English
Title

The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity

Author
Corresponding AuthorChen, Xinchun
Publication Years
2023-02-01
DOI
Source Title
ISSN
2692-9368
Abstract
Caseous granulomas are pathological hallmarks of tuberculosis (TB), and increasing evidence suggests that TB granuloma composition is highly temporally and spatially heterogenous in both animal models and humans. Traditional pathological techniques are limited in their ability to reveal the heterogeneity present in TB granulomas. Multiplex tissue imaging tools combined with powerful, high resolution spatial analysis have enabled the detection of various cell phenotypes, aiding in the visualization of the granuloma complex and revealing the interactions between immune cells and nonimmune cells. This updated understanding of tuberculous granuloma heterogeneity offers vital insights for researchers aiming to uncover the immunoregulatory mechanisms underlying granuloma formation during TB pathogenesis. More detailed granuloma classification systems will also be of use for precision medicine, and for identifying biological targets for host-directed therapeutics in TB patients.This article is categorized under:Infectious Diseases > Genetics/Genomics/EpigeneticsInfectious Diseases > Biomedical EngineeringInfectious Diseases > Molecular and Cellular Physiology
Keywords
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Others
Funding Project
Natural Science Foundation of China["82100015","82072252","91942315"] ; Science and Technology Project of Shenzhen["JCY20200109105012589","KCXFZ202002011007083"]
WOS Research Area
Research & Experimental Medicine
WOS Subject
Medicine, Research & Experimental
WOS Accession No
WOS:000922619400001
Publisher
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/475092
DepartmentShenzhen People's Hospital
Affiliation
1.Shenzhen Univ, Sch Med, Dept Pathogen Biol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Peoples R China
2.Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia
3.Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1, Clin Med Coll 2,Dept Thorac Surg, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
5.Fifth Peoples Hosp Ganzhou, Ganzhou, Jiangxi, Peoples R China
Recommended Citation
GB/T 7714
Xu, Ruiyao,Xiao, Wei,Ding, Guanggui,et al. The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity[J]. WIREs Mechanisms of Disease,2023.
APA
Xu, Ruiyao.,Xiao, Wei.,Ding, Guanggui.,Zeng, Jiang.,Liu, Hui.,...&Chen, Xinchun.(2023).The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity.WIREs Mechanisms of Disease.
MLA
Xu, Ruiyao,et al."The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity".WIREs Mechanisms of Disease (2023).
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