| Title | The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity |
| Author | |
| Corresponding Author | Chen, Xinchun |
| Publication Years | 2023-02-01
|
| DOI | |
| Source Title | |
| ISSN | 2692-9368
|
| Abstract | Caseous granulomas are pathological hallmarks of tuberculosis (TB), and increasing evidence suggests that TB granuloma composition is highly temporally and spatially heterogenous in both animal models and humans. Traditional pathological techniques are limited in their ability to reveal the heterogeneity present in TB granulomas. Multiplex tissue imaging tools combined with powerful, high resolution spatial analysis have enabled the detection of various cell phenotypes, aiding in the visualization of the granuloma complex and revealing the interactions between immune cells and nonimmune cells. This updated understanding of tuberculous granuloma heterogeneity offers vital insights for researchers aiming to uncover the immunoregulatory mechanisms underlying granuloma formation during TB pathogenesis. More detailed granuloma classification systems will also be of use for precision medicine, and for identifying biological targets for host-directed therapeutics in TB patients.This article is categorized under:Infectious Diseases > Genetics/Genomics/EpigeneticsInfectious Diseases > Biomedical EngineeringInfectious Diseases > Molecular and Cellular Physiology |
| Keywords | |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | Others
|
| Funding Project | Natural Science Foundation of China["82100015","82072252","91942315"]
; Science and Technology Project of Shenzhen["JCY20200109105012589","KCXFZ202002011007083"]
|
| WOS Research Area | Research & Experimental Medicine
|
| WOS Subject | Medicine, Research & Experimental
|
| WOS Accession No | WOS:000922619400001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/475092 |
| Department | Shenzhen People's Hospital |
| Affiliation | 1.Shenzhen Univ, Sch Med, Dept Pathogen Biol, Guangdong Prov Key Lab Reg Immun & Dis, Shenzhen, Peoples R China 2.Univ Sydney, Fac Med & Hlth, Sch Med Sci, Sydney, NSW, Australia 3.Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1, Clin Med Coll 2,Dept Thorac Surg, Shenzhen, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China 5.Fifth Peoples Hosp Ganzhou, Ganzhou, Jiangxi, Peoples R China |
| Recommended Citation GB/T 7714 |
Xu, Ruiyao,Xiao, Wei,Ding, Guanggui,et al. The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity[J]. WIREs Mechanisms of Disease,2023.
|
| APA |
Xu, Ruiyao.,Xiao, Wei.,Ding, Guanggui.,Zeng, Jiang.,Liu, Hui.,...&Chen, Xinchun.(2023).The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity.WIREs Mechanisms of Disease.
|
| MLA |
Xu, Ruiyao,et al."The use of multiplex imaging techniques to characterize tuberculous granuloma heterogeneity".WIREs Mechanisms of Disease (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment