| Title | Asymmetric Total Synthesis of Twin Bufogargarizins A and B |
| Author | |
| Corresponding Author | Li, Chuang-Chuang |
| Publication Years | 2023
|
| DOI | |
| Source Title | |
| ISSN | 0002-7863
|
| EISSN | 1520-5126
|
| Abstract | The first and asymmetric total synthesis of bufogargarizins A and B, two unusual and highly oxygenated twin steroids with rearranged A/B rings, was achieved. The synthetically challenging [7-5-6-5] tetracyclic ring system of bufogargarizin A was efficiently constructed by the first intramolecular Ru-catalyzed [5 + 2] cycloaddition reaction of a vinyl ether cyclopropane-yne. Notably, the interesting [5-7-6-5] tetracyclic skeleton of bufogargarizin B was diastereoselectively reassembled by unique retroaldol/transannular aldol cascade reactions from the [7-5-6-5] tetracyclic framework. |
| URL | [Source Record] |
| Indexed By | |
| Language | English
|
| Important Publications | NI Journal Papers
|
| SUSTech Authorship | First
; Corresponding
|
| Funding Project | National Natural Science Foundation of China["21971105","22225102"]
; Shenzhen Bay Laboratory[2021KCXTD024]
; Research Projects of Universities of Guangdong Province["2019KZDXM005","2020JGXM100"]
; Graduate Education Innovation Program of Guangdong Province[JCYJ20210324104408023]
; Shenzhen Science and Technology Innovation Committee[2022YFE0205500]
; null[SZBL2021080601005]
|
| WOS Research Area | Chemistry
|
| WOS Subject | Chemistry, Multidisciplinary
|
| WOS Accession No | WOS:000923258600001
|
| Publisher | |
| Data Source | Web of Science
|
| Citation statistics |
Cited Times [WOS]:2
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/475096 |
| Department | Department of Chemistry 深圳格拉布斯研究院 |
| Affiliation | 1.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Dept Chem, Guangdong Prov Key Lab Catalyt Chem y, Shenzhen 518055, Peoples R China 2.Shenzhen Bay Lab, Shenzhen 518132, Peoples R China |
| First Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
| Corresponding Author Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
| First Author's First Affilication | Department of Chemistry; Shenzhen Grubbs Institute |
| Recommended Citation GB/T 7714 |
Zhong, Li-Ping,Feng, Rui,Wang, Jing-Jing,et al. Asymmetric Total Synthesis of Twin Bufogargarizins A and B[J]. Journal of the American Chemical Society,2023.
|
| APA |
Zhong, Li-Ping,Feng, Rui,Wang, Jing-Jing,&Li, Chuang-Chuang.(2023).Asymmetric Total Synthesis of Twin Bufogargarizins A and B.Journal of the American Chemical Society.
|
| MLA |
Zhong, Li-Ping,et al."Asymmetric Total Synthesis of Twin Bufogargarizins A and B".Journal of the American Chemical Society (2023).
|
| Files in This Item: | There are no files associated with this item. | |||||
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