Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging

Chang, Zong1,2; Liu, Liangjian1,2,3,4; Zhai, Jingying5; Liu, Chenchen1,2; Wang, Xiao6; Liu, Chengbo1,2; Xie, Xiaojiang5; Sun, Qinchao1,2

2023

10.1021/acs.chemmater.2c03377

CHEMISTRY OF MATERIALS   Impact Factor & Quartile

0897-4756

1520-5002

Molecular electronic coupling has been found to play a crucial role in the light-induced processes of natural and artificial systems. The light-induced acoustic process (photoacoustic) is also considered to be one of the most essential characters of the light-absorbing molecules. Herein, we report an interesting observation of the molecular electronic coupling-induced photoacoustic effect (MECPA) in which the PA intensity is dominated by the molecular electronic coupling, rather than the absorption intensity as usually concerned. The molecular electronic coupling effect results in a significant exciton absorption suppression from the monomer to pentamer. However, the corresponding PA efficiency was found to be approximately 2 orders of magnitude greater for the latter. A well-behaved linear correlation between the molecular exciton absorbance and PA efficiency was observed. The surprisingly significant MECPA effect was realized via novel NIR-II squaraine-benzothiopyrylium dyes. Excellent photophysical properties of the novel NIR-II dyes were achieved, such as a large absorption extinction coefficient and high photostability. In vivo duplex PA imaging was demonstrated for tumor tissue and macrophage cells and blood and lymphoid vessels. The MECPA effect would open a new window for the design of PA contrast agent systems for in vivo imaging.

SCI

English

Corresponding

National Natural Science Foundation of China["22077135","21905296"] ; Guangdong Basic and Applied Basic Research Foundation[2020B121201010] ; Natural Science Foundation of Shenzhen[JCYJ20200109115633343]

Chemistry ; Materials Science

Chemistry, Physical ; Materials Science, Multidisciplinary

WOS:000925400200001

AMER CHEMICAL SOC

MATERIALS SCIENCE

Web of Science

1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Prov Key Lab Biomed Opt Imaging Technol, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Biomed Opt & Mol Imaging, Shenzhen 518055, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen 518055, Guangdong, Peoples R China
4.Natl Innovat Ctr Adv Med Devices, Shenzhen 518131, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
6.Chinese Acad Sci, Shenzhen Inst AdvancedTechnol, Shenzhen Key Lab Nanobiomechan, Shenzhen 518055, Guangdong, Peoples R China

Chang, Zong,Liu, Liangjian,Zhai, Jingying,et al. Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging[J]. CHEMISTRY OF MATERIALS,2023.

Chang, Zong.,Liu, Liangjian.,Zhai, Jingying.,Liu, Chenchen.,Wang, Xiao.,...&Sun, Qinchao.(2023).Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging.CHEMISTRY OF MATERIALS.

Chang, Zong,et al."Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging".CHEMISTRY OF MATERIALS (2023).