中文版 | English
Title

Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging

Author
Corresponding AuthorLiu, Chengbo; Xie, Xiaojiang; Sun, Qinchao
Publication Years
2023
DOI
Source Title
ISSN
0897-4756
EISSN
1520-5002
Abstract
Molecular electronic coupling has been found to play a crucial role in the light-induced processes of natural and artificial systems. The light-induced acoustic process (photoacoustic) is also considered to be one of the most essential characters of the light-absorbing molecules. Herein, we report an interesting observation of the molecular electronic coupling-induced photoacoustic effect (MECPA) in which the PA intensity is dominated by the molecular electronic coupling, rather than the absorption intensity as usually concerned. The molecular electronic coupling effect results in a significant exciton absorption suppression from the monomer to pentamer. However, the corresponding PA efficiency was found to be approximately 2 orders of magnitude greater for the latter. A well-behaved linear correlation between the molecular exciton absorbance and PA efficiency was observed. The surprisingly significant MECPA effect was realized via novel NIR-II squaraine-benzothiopyrylium dyes. Excellent photophysical properties of the novel NIR-II dyes were achieved, such as a large absorption extinction coefficient and high photostability. In vivo duplex PA imaging was demonstrated for tumor tissue and macrophage cells and blood and lymphoid vessels. The MECPA effect would open a new window for the design of PA contrast agent systems for in vivo imaging.
URL[Source Record]
Indexed By
Language
English
SUSTech Authorship
Corresponding
Funding Project
National Natural Science Foundation of China["22077135","21905296"] ; Guangdong Basic and Applied Basic Research Foundation[2020B121201010] ; Natural Science Foundation of Shenzhen[JCYJ20200109115633343]
WOS Research Area
Chemistry ; Materials Science
WOS Subject
Chemistry, Physical ; Materials Science, Multidisciplinary
WOS Accession No
WOS:000925400200001
Publisher
ESI Research Field
MATERIALS SCIENCE
Data Source
Web of Science
Citation statistics
Cited Times [WOS]:0
Document TypeJournal Article
Identifierhttp://kc.sustech.edu.cn/handle/2SGJ60CL/475098
DepartmentDepartment of Chemistry
Affiliation
1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Guangdong Prov Key Lab Biomed Opt Imaging Technol, Shenzhen 518055, Guangdong, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Biomed Opt & Mol Imaging, Shenzhen 518055, Guangdong, Peoples R China
3.Univ Chinese Acad Sci, Shenzhen Coll Adv Technol, Shenzhen 518055, Guangdong, Peoples R China
4.Natl Innovat Ctr Adv Med Devices, Shenzhen 518131, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
6.Chinese Acad Sci, Shenzhen Inst AdvancedTechnol, Shenzhen Key Lab Nanobiomechan, Shenzhen 518055, Guangdong, Peoples R China
Corresponding Author AffilicationDepartment of Chemistry
Recommended Citation
GB/T 7714
Chang, Zong,Liu, Liangjian,Zhai, Jingying,et al. Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging[J]. CHEMISTRY OF MATERIALS,2023.
APA
Chang, Zong.,Liu, Liangjian.,Zhai, Jingying.,Liu, Chenchen.,Wang, Xiao.,...&Sun, Qinchao.(2023).Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging.CHEMISTRY OF MATERIALS.
MLA
Chang, Zong,et al."Molecular Electronic Coupling-Induced Photoacoustics for NIR-I/II Duplex in Vivo Imaging".CHEMISTRY OF MATERIALS (2023).
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