| Title | Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer |
| Author | |
| Corresponding Author | Jin‑Tang Dong |
| Joint first author | Qingqing Huang; Mingcheng Liu |
| Publication Years | 2023-02-21
|
| DOI | https://doi.org/10.1186/s12916-023-02763-4 |
| Source Title | |
| Abstract | Castration-resistant prostate cancer often metastasizes to the bone, and such bone metastases eventually become resistant to available therapies, leading to the death of patients. Enriched in the bone, TGF-β plays a pivotal role in bone metastasis development. However, directly targeting TGF-β or its receptors has been challenging for the treatment of bone metastasis. We previously found that TGF-β induces and then depends on the acetylation of transcription factor KLF5 at K369 to regulate multiple biological processes, including the induction of EMT, cellular invasiveness, and bone metastasis. Acetylated KLF5 (Ac-KLF5) and its downstream efectors are thus potential therapeutic targets for treating TGF-β-induced bone metastasis in prostate cancer |
| Indexed By | |
| Language | English
|
| SUSTech Authorship | First
; 共同第一
; Corresponding
|
| Data Source | 人工提交
|
| Citation statistics |
Cited Times [WOS]:0
|
| Document Type | Journal Article |
| Identifier | http://kc.sustech.edu.cn/handle/2SGJ60CL/475106 |
| Department | Department of Human Cell Biology and Genetics 南方科技大学医学院 |
| Affiliation | 1.Department of Human Cell Biology and Genetics, School of Medicine, Southern University of Science and Technology 2.Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, the Seventh Afliated Hospital, Sun Yat-sen University |
| First Author Affilication | Department of Human Cell Biology and Genetics; School of Medicine |
| Corresponding Author Affilication | Department of Human Cell Biology and Genetics; School of Medicine |
| First Author's First Affilication | Department of Human Cell Biology and Genetics; School of Medicine |
| Recommended Citation GB/T 7714 |
Qingqing Huang,Mingcheng Liu,Duo Zhang,et al. Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer[J]. BMC Medicine,2023.
|
| APA |
Qingqing Huang.,Mingcheng Liu.,Duo Zhang.,Bing‑Biao Lin.,Xing Fu.,...&Jin‑Tang Dong.(2023).Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer.BMC Medicine.
|
| MLA |
Qingqing Huang,et al."Nitazoxanide inhibits acetylated KLF5-induced bone metastasis by modulating KLF5 function in prostate cancer".BMC Medicine (2023).
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| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Nitazoxanide inhibit（4762KB） | Open Access | -- | View | |||
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