Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project

Tong, Ye1,2,3; Liu, Fangchao2,3; Huang, Keyong2,3; Li, Jianxin2,3; Yang, Xueli4; Chen, Jichun2,3; Liu, Xiaoqing5,6; Cao, Jie2,3; Chen, Shufeng2,3; Yu, Ling7; Zhao, Yingxin8; Wu, Xianping9; Zhao, Liancheng2,3; Li, Ying2,3; Hu, Dongsheng10,11; Huang, Jianfeng2,3; Lu, Xiangfeng2,3; Shen, Chong1,12; Gu, Dongfeng1,2,3,13

2023

10.1111/1753-0407.13350

Journal of Diabetes   Impact Factor & Quartile

1753-0393

1753-0407

BackgroundThe effect of long-standing prediabetes or its transition on incident cardiovascular disease (CVD) is unclear. This study aimed to evaluate the association of changes in fasting blood glucose (FBG) status with the risk of developing CVD. MethodsThis research included 12 145 Chinese adults aged 35-74 years and free from diabetes mellitus (DM) at baseline. Study participants were cross-classified into six categories according to glucose at the first (1998-2001) and the second visit after 8 years: normal fasting glucose (NFG; 50-99 mg/dl), impaired FBG (IFG; 100-125 mg/dl), and DM. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for CVD associated with transition of glucose status. ResultsDuring a median follow-up of 5.5 years, 373 incident CVD cases occurred. Compared with participants remaining persistent NFG, a higher risk of developing CVD was identified among those remaining persistent IFG, progressing to DM from NFG or from IFG, with the multivariate-adjusted HR (95% CI) of 1.792 (1.141, 2.816), 1.723 (1.122, 2.645) and 1.946 (1.120, 3.381), respectively. Furthermore, when stratified by glucose status at baseline, persistent IFG and progression from IFG to DM still increased CVD risk in comparison with reversion from IFG to NFG, with the multivariate-adjusted HR (95% CI) of 1.594 (1.003, 2.532) and 1.913 (1.080, 3.389). ConclusionsParticipants with long-standing IFG and progressing to DM had a higher risk of developing CVD. Further well-designed studies are warranted to assess the association of other phenotypes or prediabetes duration with CVD.

cardiovascular disease Chinese population impaired fasting blood glucose prospective cohort study

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Endocrinology & Metabolism

Endocrinology & Metabolism

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1.Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol, Ctr Global Hlth, Nanjing 211166, Peoples R China
2.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Key Lab Cardiovasc Epidemiol, Beijing, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Dept Epidemiol, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China
4.Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin Key Lab Environm, Tianjin, Peoples R China
5.Guangdong Prov Peoples Hosp, Div Epidemiol, Guangzhou, Guangdong, Peoples R China
6.Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China
7.Fujian Prov Hosp, Dept Cardiol, Fuzhou, Peoples R China
8.Shandong Acad Med Sci, Inst Basic Med, Cardio Cerebrovasc Control & Res Ctr, Jinan, Peoples R China
9.Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China
10.Zhengzhou Univ, Dept Epidemiol & Hlth Stat, Coll Publ Hlth, Zhengzhou, Peoples R China
11.Shenzhen Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hlth Sci Ctr, Shenzhen, Peoples R China
12.Chinese Acad Med Sci, Res Units Cohort Study Cardiovasc Dis, Beijing, Peoples R China
13.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China

Tong, Ye,Liu, Fangchao,Huang, Keyong,et al. Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project[J]. Journal of Diabetes,2023.

Tong, Ye.,Liu, Fangchao.,Huang, Keyong.,Li, Jianxin.,Yang, Xueli.,...&Gu, Dongfeng.(2023).Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project.Journal of Diabetes.

Tong, Ye,et al."Changes in fasting blood glucose status and incidence of cardiovascular disease: The China-PAR project".Journal of Diabetes (2023).