Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3-PEDF/HIF-1 alpha - MMP-2/MMP-9 signaling in macrophages

Tian, Yanfeng1; Sheng, Siqi1; Gao, Weiwei1; Yao, Jianting1; Tian, Ye1,2

2022-12-27

10.1371/journal.pone.0279191

PLoS One   Impact Factor & Quartile

1932-6203

["Background","The rupture of vulnerable atherosclerotic plaque is the main cause of acute ischemic vascular events, and is characterized by pathological degradation of matrix collagen in the fibrous cap. In a previous study, we reported that 5-aminolevulinic acid-mediated sonodynamic therapy suppressed collagen degradation in rabbit plaque. However, the underlying molecular mechanism has yet to be fully elucidated.","Methods","We applied sinoporphyrin sodium-mediated sonodynamic therapy (DVDMS-SDT) to balloon-denuded rabbit and apolipoprotein E-deficient (ApoE-/-) mouse models to observe collagen content in plaque. Cultured human THP-1 and mouse peritoneal macrophage-derived foam cells were used for in vitro mechanistic studies.","Results","We observed that DVDMS-SDT decreased plaque area and increased the percentages of collagen and smooth muscle cells and reduced the percentage of macrophages in rabbit and ApoE-/- mouse advanced plaques. In vitro, DVDMS-SDT modulated the caspase 3-pigment epithelium-derived factor/hypoxia-inducible factor-1 alpha (PEDF/HIF-1 alpha)-matrix metalloprotease-2/9 (MMP-2/MMP-9) signaling in macrophage foam cells.","Conclusions","Our findings show that DVDMS-SDT effectively inhibits matrix collagen degradation in advanced atherosclerotic plaque by modulating caspase 3-PEDF/HIF-1 alpha-MMP-2/MMP-9 signaling in macrophage foam cells and therefore represents a suitable and promising clinical regimen to stabilize vulnerable plaques."]

SCI

English

Corresponding

State Key Program of National Natural Science Foundation of China[81530052] ; major scientific instrument equipment development project of China[81727809] ; National Natural Science Foundation of China[82102052] ; Innovative Scientific Research Project of Harbin Medical University[2021-KYYWF-0225]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000924525200018

PUBLIC LIBRARY SCIENCE

Web of Science

1.Harbin Med Univ, Affiliated Hosp 1, Cardiovasc Inst, Dept Cardiol, Harbin, Peoples R China
2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen, Affiliated Hosp 2, Shenzhen, Peoples R China

Tian, Yanfeng,Sheng, Siqi,Gao, Weiwei,et al. Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3-PEDF/HIF-1 alpha - MMP-2/MMP-9 signaling in macrophages[J]. PLoS One,2022,17(12).

Tian, Yanfeng,Sheng, Siqi,Gao, Weiwei,Yao, Jianting,&Tian, Ye.(2022).Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3-PEDF/HIF-1 alpha - MMP-2/MMP-9 signaling in macrophages.PLoS One,17(12).

Tian, Yanfeng,et al."Sonodynamic therapy suppresses matrix collagen degradation in vulnerable atherosclerotic plaque by modulating caspase 3-PEDF/HIF-1 alpha - MMP-2/MMP-9 signaling in macrophages".PLoS One 17.12(2022).