Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance

Liu, Chunchen1; Li, Mengfei2; Ma, Huilong1; Hu, Zhubin3; Wang, Xinyuan1; Ma, Rui1; Jiang, Yingying4; Sun, Haitao3,5; Zhu, Shoujun2; Liang, Yongye1

2023-01-11

RESEARCH   Impact Factor & Quartile

2096-5168

2639-5274

The second near-infrared (NIR-II, 1000-1700 nm) molecular fluorophores containing donor-acceptor-donor (D-A-D) conjugated backbone have attracted substantial attention due to their outstanding advantages, such as stable emission and facilely tuned photophysical properties. However, it is still challenging for them to simultaneously achieve high brightness and red-shifted absorption and emission. Herein, furan is adopted as the D unit to construct NIR-II fluorophores, demonstrating red-shift of absorption, enhanced absorption coefficient and fluorescent quantum yield when compared with the generally used thiophene counterparts. The high brightness and desirable pharmacokinetics of the optimized fluorophore, IR-FFCHP, endows improved performance for angiography and tumor-targeting imaging. Furthermore, dual-NIR-II imaging of tumor and sentinel lymph nodes (LNs) has been achieved with IR-FFCHP and PbS/CdS quantum dots, enabling the in vivo imaging navigated LNs surgery in tumor-bearing mise. This work demonstrates the potential of furan for constructing bright NIR-II fluorophores for biological imaging.

NIR-II molecular fluorophores donor engineering furan cyclic side chains biological imaging

SCI

English

First ; Corresponding

National Natural Science Foundation of China["21772084","12034008"] ; Fundamental Research Layout of Shenzhen[JCY20180504165657443] ; Guangdong Provincial Natural Science Foundation-Yueshen Joint Funding (Youth Project)[2019A1515110464] ; Shenzhen Science and Technology Commission-free exploration/general project[JCYJ20190812151209348] ; Shanghai Rising StarProgram[21QA1402600] ; Chinese Scholarship Council[201808440345]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:000923633600001

AMER ASSOC ADVANCEMENT SCIENCE

Web of Science

1.Southern Univ Sci & Technol, Dept Mat Sci & Engn, Shenzhen Key Lab Printed Organ Elect, Shenzhen 518055, Peoples R China
2.Jilin Univ, Coll Chem, State Key Lab Supramol Struct & Mat, Changchun 130012, Peoples R China
3.East China Normal Univ, Sch Phys & Elect Sci, State Key Lab Precis Spect, Shanghai 200241, Peoples R China
4.Stanford Univ, Dept Chem, Stanford, CA 94305 USA
5.Shanxi Univ, Collaborat Innovat Ctr Extreme Opt, Taiyuan 030006, Shanxi, Peoples R China

Liu, Chunchen,Li, Mengfei,Ma, Huilong,et al. Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance[J]. RESEARCH,2023,2023.

Liu, Chunchen.,Li, Mengfei.,Ma, Huilong.,Hu, Zhubin.,Wang, Xinyuan.,...&Liang, Yongye.(2023).Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance.RESEARCH,2023.

Liu, Chunchen,et al."Furan Donor for NIR-II Molecular Fluorophores with Enhanced Bioimaging Performance".RESEARCH 2023(2023).