Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

Cen, Yinghuan1,2; Chen, Letian1,2; Liu, Zihao3; Lin, Qun1,2; Fang, Xiaolin1,2; Yao, Herui1,2; Gong, Chang1,2

2023-02-09

10.1038/s41420-023-01352-x

CELL DEATH DISCOVERY   Impact Factor & Quartile

2058-7716

Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.

SCI

English

Others

Natural Science Foundation of China["81872139","82072907"] ; Project of The Beijing Xisike Clinical Oncology Research Foundation[Y-Roche2019/2-0078\Y-pierrefabre202102-0107] ; Technology Development Program of Guangdong province[2021A0505030082] ; Project of The Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation[2020B1212060018] ; null[2022005]

Cell Biology

Cell Biology

WOS:000931464000001

SPRINGERNATURE

Web of Science

1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou 510120, Peoples R China
2.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Breast Tumor Ctr, Guangzhou 510120, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Breast & Thyroid Surg,Clin, Shenzhen 518020, Peoples R China

Cen, Yinghuan,Chen, Letian,Liu, Zihao,et al. Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics[J]. CELL DEATH DISCOVERY,2023,9(1).

Cen, Yinghuan.,Chen, Letian.,Liu, Zihao.,Lin, Qun.,Fang, Xiaolin.,...&Gong, Chang.(2023).Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics.CELL DEATH DISCOVERY,9(1).

Cen, Yinghuan,et al."Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics".CELL DEATH DISCOVERY 9.1(2023).